Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/27384
Title: DNA gel particles: an overview
Authors: Morán, M. Carmen 
Vinardell, M. Pilar 
Infante, M. Rosa 
Miguel, M. Graça 
Lindman, Björn 
Keywords: DNA gels; DNA–oppositely charged agent interaction; Particles; DNA release; Hemocompatibility; Cytotoxicity
Issue Date: Mar-2014
Publisher: Elsevier
Citation: MORÁN, M. Carmen [et. al] - DNA gel particles: an overview. "Advances in Colloid and Interface Science". ISSN 0001-8686. Vol. 205 (2014) p. 240-256
Serial title, monograph or event: Advances in Colloid and Interface Science
Volume: 205
Abstract: A general understanding of interactions between DNA and oppositely charged compounds forms the basis for developing novel DNA-based materials, including gel particles. The association strength, which is altered by varying the chemical structure of the cationic cosolute, determines the spatial homogeneity of the gelation process, creating DNA reservoir devices and DNA matrix devices that can be designed to release either single- (ssDNA) or double-stranded (dsDNA) DNA. This review covers recent developments on the topic of DNA gel particles formed in water–water emulsion-type interfaces. The degree of DNA entrapment, particle morphology, swelling/dissolution behavior and DNA release responses are discussed as functions of the nature of the cationic agent used. On the basis of designing DNA gel particles for therapeutic purposes, recent studies on the determination of the surface hydrophobicity and the hemolytic and the cytotoxic assessments of the obtained DNA gel particles have been also reported.
URI: http://hdl.handle.net/10316/27384
ISSN: 0001-8686
DOI: 10.1016/j.cis.2013.09.002
Rights: openAccess
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais

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