Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/25615
Title: Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation
Authors: Teodoro, João Soeiro 
Duarte, Filipe Valente 
Gomes, Ana Patrícia 
Varela, Ana Teresa 
Peixoto, Francisco Manuel 
Rolo, Anabela Pinto 
Palmeira, C. M. 
Keywords: Berberine; Mitochondrial function; Liver bioenergetics; Obesity; SirT3
Issue Date: 2013
Publisher: Elsevier B.V.
Serial title, monograph or event: Mitochondrion
Volume: 13
Issue: 6
Abstract: Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of liver and thus hepaticmitochondria inwhole-bodymetabolism, berberine effects on hepaticmitochondrial function in an obesity model are still unknown. Here, we demonstrate that berberine treatment recovers mitochondrial efficiency when altered by a high-fat feeding.Mitochondria isolated from the liver of high-fat fed rats exhibited decreased capacity to accumulate calcium and impaired oxidative phosphorylation (OXPHOS) capacity, as shown by impaired mitochondrialmembrane potential, oxygen consumption and cellular ATP levels. Interestingly, the recovery of mitochondrial function by berberine was associated with an increased activity of the mitochondrial sirtuin 3 (SirT3). In conclusion, berberine potent protective effects against metabolic syndrome may rely on increasing mitochondrial SirT3 activity, normalizing mitochondrial function and preventing a state of energetic deficit caused by impaired OXPHOS.
URI: http://hdl.handle.net/10316/25615
DOI: 10.1016/j.mito.2013.09.002
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

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