Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/21648
Título: Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers
Autor: Natu, Mădălina V. 
Sousa, Hermínio C. de 
Gil, M. H. 
Palavras-chave: Electrospinning; Bicomponent fibers; Drug release; Modeling
Data: Set-2010
Editora: Elsevier
Citação: NATU, Mădălina V.; SOUSA, Hermínio C. de; GIL, M. H. - Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers. "International Journal of Pharmaceutics". ISSN 0378-5173. 397:1–2 (2010) 50–58
Título da revista, periódico, livro ou evento: International Journal of Pharmaceutics
Volume: 397
Número: 1-2
Resumo: Bicomponent fibers of two semi-crystalline (co)polymers, poly(ɛ-caprolactone), and poly(oxyethylene-b-oxypropylene-b-oxyethylene), were obtained by electrospinning. Acetazolamide and timolol maleate were loaded in the fibers in different concentrations (below and above the drug solubility limit in polymer) in order to determine the effect of drug solubility in polymer, drug state, drug loading and fiber composition on fiber morphology, drug distribution and release kinetics. The high loadings fibers (with drug in crystalline form) showed higher burst and faster release than low drug content fibers, indicating the release was more sustained when the drug was encapsulated inside the fibers, in amorphous form. Moreover, timolol maleate was released faster than acetazolamide, indicating that drug solubility in polymer influences the partition of drug between polymer and elution medium, while fiber composition also controlled drug release. At low loadings, total release was not achieved (cumulative release percentages smaller than 100%), suggesting that drug remained trapped in the fibers. The modeling of release data implied a three stage release mechanism: a dissolution stage, a desorption and subsequent diffusion through water-filled pores, followed by polymer degradation control.
URI: https://hdl.handle.net/10316/21648
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2010.06.045
Direitos: openAccess
Aparece nas coleções:FCTUC Eng.Química - Artigos em Revistas Internacionais

Ficheiros deste registo:
Mostrar registo em formato completo

Citações SCOPUSTM   

146
Visto em 25/mar/2024

Citações WEB OF SCIENCETM
1

135
Visto em 2/mar/2024

Visualizações de página

308
Visto em 26/mar/2024

Downloads 20

912
Visto em 26/mar/2024

Google ScholarTM

Verificar

Altmetric

Altmetric


Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.