Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/21647
Title: Controlled release gelatin hydrogels and lyophilisates with potential application as ocular inserts
Authors: Natu, Mădălina V. 
Sardinha, José P. 
Correia, Ilídio J. 
Gil, M. H. 
Issue Date: Dec-2007
Publisher: IOP Publishing
Serial title, monograph or event: Biomedical Materials
Volume: 2
Issue: 4
Abstract: Hydrogels and lyophilisates were obtained by chemical crosslinking of gelatin using N-hydroxysuccinimide and N, N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride. The systems were characterized with respect to the degree of crosslinking, morphology, water uptake, in vitro drug release and biocompatibility studies. Pilocarpine hydrochloride, a drug for the treatment of glaucoma, was loaded by soaking in an aqueous solution containing the drug. In vitro, the released drug percentage varied between 29.2% and 99.2% in 8 h of study. The release data were fitted to the Korsmeyer–Peppas equation to calculate the release exponent, which indicated anomalous transport for the release of pilocarpine. The corneal endothelial cell culture tests indicated that the prepared biomaterials are not cytotoxic.
URI: http://hdl.handle.net/10316/21647
ISSN: 1748-6041
DOI: 10.1088/1748-6041/2/4/006
Rights: closedAccess
Appears in Collections:FCTUC Eng.Química - Artigos em Revistas Internacionais

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