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|Title:||A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug||Authors:||Natu, Mădălina V.
Gaspar, Manuel N.
Ribeiro, Carlos A. Fontes
Correia, Ilídio J.
Sousa, Hermínio C. de
Gil, M. H.
|Issue Date:||2011||Publisher:||IOP Publishing||Citation:||NATU, Mădălina V. [et al.] - A poly(ε-caprolactone) device for sustained release of an anti-glaucoma drug. "Biomedical Materials". ISSN 1748-60416. 6:2 (2011) 9 p.||Serial title, monograph or event:||Biomedical Materials||Volume:||6||Issue:||2||Abstract:||Implantable dorzolamide-loaded discs were prepared by blending poly(ε-caprolactone), PCL, with poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide), Lu. By blending, crystallinity, water uptake and mass loss were modified relative to the pure polymers. Burst was diminished by coating the discs with a PCL shell. All samples presented burst release except PCL-coated samples that showed controlled release during 18 days. For PCL-coated samples, barrier control of diffusion coupled with partition control from the core slowed down the release, while for 50/50 Lu/PCL-coated samples, the enhancement in the porosity of the core diminished partition control of drug release. Nonlinear regression analysis suggested that a degradation model fully describes the release curve considering a triphasic release mechanism: the instantaneous diffusion (burst), diffusion and polymer degradation stages. The MTT test indicated that the materials are not cytotoxic for corneal endothelial cells. A good in vitro–in vivo correlation was obtained, with similar amounts of drug released in vitro and in vivo. The discs decreased intraocular pressure (IOP) in normotensive rabbit eyes by 13.0% during 10 days for PCL-coated and by 13.0% during 4 days for 50/50 Lu/PCL-coated samples. The percentages of IOP decrease are similar to those obtained by dorzolamide eyedrop instillation (11.0%).||URI:||http://hdl.handle.net/10316/21646||ISSN:||1748-6041||DOI:||10.1088/1748-6041/6/2/025003||Rights:||closedAccess|
|Appears in Collections:||FMUC Medicina - Artigos em Revistas Internacionais|
FCTUC Eng.Química - Artigos em Revistas Internacionais
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