Cigarette Smoking Increases Oxidative Stress in Prostate Cancer Patients – A Preliminary Study

Abstract

Cigarette smoke is an oxidant, creating free radicals that are involved in carcinogenesis namely in Prostate Cancer (PC). However, a correlation between cigarette smoking and PC progression remains unclear. This study was directed to evaluate the correlation between cigarette smoking, Oxidative Stress (OS) and PC development and progression. The Total Antioxidant Status (TAS), Glutathione (GSH) and Malondialdehyde (MDA) were analysed in the plasma and/or in the erythrocytes of PC patients, 5 smokers and 9 non-smokers and in controls, 2 smokers and 4 non-smokers. Our results show a significantly decrease in TAS and GSH, and an increase in MDA levels, in PC smoker group. These results suggest that cigarette smoking may be involved in prostate carcinogenesis.