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https://hdl.handle.net/10316/11789
Título: | Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage | Autor: | Rosa, Susana C. Gonçalves, Juliana Judas, Fernando Mobasheri, Ali Lopes, Celeste Mendes, Alexandrina Ferreira |
Palavras-chave: | diabetes mellitus; osteoartrite | Data: | 2-Jun-2009 | Editora: | BioMedCentral | Citação: | ROSA, Susana C. et al. - Impaired glucose transporter-1 degradation and increased glucose transport and oxidative stress in response to high glucose in chondrocytes from osteoarthritic versus normal human cartilage. Arthritis Research & Therapy Vol 11 No 3.R80 | Resumo: | Introduction Disorders that affect glucose metabolism, namely diabetes mellitus (DM), may favor the development and/or progression of osteoarthritis (OA). Thus far, little is known regarding the ability of chondrocytes to adjust to variations in the extracellular glucose concentration, resulting from hypoglycemia and hyperglycemia episodes, and so, to avoid deleterious effects resulting from deprivation or intracellular accumulation of glucose. The aim of this study was to compare the ability of normal and OA chondrocytes to regulate their glucose transport capacity in conditions of insufficient or excessive extracellular glucose and to identify the mechanisms involved and eventual deleterious consequences, namely the production of reactive oxygen species (ROS). | URI: | https://hdl.handle.net/10316/11789 | DOI: | 10.1186/ar2713 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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AR&T_2009.pdf | 1.45 MB | Adobe PDF | Ver/Abrir |
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