Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/11628
Título: A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia
Autor: Matafome, P. 
Nunes, E. 
Louro, T. 
Amaral, C. 
Crisóstomo, J. 
Rodrigues, L. 
Moedas, A. R. 
Monteiro, P. 
Cipriano, A. 
Seiça, R. 
Palavras-chave: Liver; Inflammation; Atorvastatin; Insulin treatment
Data: Mar-2009
Editora: Springer
Citação: Naunyn-Schmiedeberg's Archives of Pharmacology. 379:3 (2009) 241-251
Resumo: Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto–Kakizaki rats were fed with a high-fat diet to test hepatic effects of type 2 diabetes with hyperlipidemia and the effect of atorvastatin and insulin, individually and in combination, in systemic and hepatic inflammatory and oxidative stress markers. High-fat diet aggravated fasting glycemia, systemic and liver lipids, and inflammatory and oxidative stress markers. Individual treatments improved glycemic and lipid profiles, but failed to improve inflammatory markers, whereas insulin was able to reduce liver oxidative stress parameters. Combination of insulin and atorvastatin further improved glycemic and lipid profiles and decreased circulating C-reactive protein levels and liver inflammatory and oxidative stress markers. Insulin and atorvastatin combination leads to better glycaemic and lipid profiles and to better protection against liver inflammation and oxidative stress, giving a superior level of liver protection in type 2 diabetic with hyperlipidemia.
URI: https://hdl.handle.net/10316/11628
ISSN: 0028-1298
DOI: 10.1007/s00210-008-0363-y
Direitos: openAccess
Aparece nas coleções:FMUC Medicina - Artigos em Revistas Internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato
A role for atorvastatin and insulin combination.pdf430.04 kBAdobe PDFVer/Abrir
Mostrar registo em formato completo

Citações SCOPUSTM   

20
Visto em 17/nov/2022

Citações WEB OF SCIENCETM
50

19
Visto em 15/nov/2022

Visualizações de página

346
Visto em 26/mar/2024

Downloads

340
Visto em 26/mar/2024

Google ScholarTM

Verificar

Altmetric

Altmetric


Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.