Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/109506
DC Field | Value | Language |
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dc.contributor.author | Marques, Catarina | - |
dc.contributor.author | Mega, Cristina | - |
dc.contributor.author | Gonçalves, Andreia | - |
dc.contributor.author | Rodrigues-Santos, Paulo | - |
dc.contributor.author | Lemos, Edite Teixeira de | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.contributor.author | Fontes-Ribeiro, Carlos A. | - |
dc.contributor.author | Reis, F. | - |
dc.contributor.author | Fernandes, Rosa | - |
dc.date.accessioned | 2023-10-18T09:39:40Z | - |
dc.date.available | 2023-10-18T09:39:40Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0962-9351 | pt |
dc.identifier.issn | 1466-1861 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/109506 | - |
dc.description.abstract | This study aimed to evaluate the efficacy of sitagliptin, a dipeptidyl peptidase IV (DPP-IV) inhibitor, in preventing the deleterious effects of diabetes on the kidney in an animal model of type 2 diabetes mellitus; the Zucker diabetic fatty (ZDF) rat: 20-week-old rats were treated with sitagliptin (10 mg/kg bw/day) during 6 weeks. Glycaemia and blood HbA1c levels were monitored, as well as kidney function and lesions. Kidney mRNA and/or protein content/distribution of DPP-IV, GLP-1, GLP-1R, TNF-α, IL-1β, BAX, Bcl-2, and Bid were evaluated by RT-PCR and/or western blotting/immunohistochemistry. Sitagliptin treatment improved glycaemic control, as reflected by the significantly reduced levels of glycaemia and HbA1c (by about 22.5% and 1.2%, resp.) and ameliorated tubulointerstitial and glomerular lesions. Sitagliptin prevented the diabetes-induced increase in DPP-IV levels and the decrease in GLP-1 levels in kidney. Sitagliptin increased colocalization of GLP-1 and GLP-1R in the diabetic kidney. Sitagliptin also decreased IL-1β and TNF-α levels, as well as, prevented the increase of BAX/Bcl-2 ratio, Bid protein levels, and TUNEL-positive cells which indicates protective effects against inflammation and proapoptotic state in the kidney of diabetic rats, respectively. In conclusion, sitagliptin might have a major role in preventing diabetic nephropathy evolution due to anti-inflammatory and antiapoptotic properties. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.relation | PEst-C/SAU/UI3282/2011 | pt |
dc.relation | PEst- C/SAU/UI3282/2013 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Apoptosis | pt |
dc.subject.mesh | Diabetes Mellitus, Experimental | pt |
dc.subject.mesh | Diabetes Mellitus, Type 2 | pt |
dc.subject.mesh | Dipeptidyl-Peptidase IV Inhibitors | pt |
dc.subject.mesh | Glucagon-Like Peptide 1 | pt |
dc.subject.mesh | Inflammation | pt |
dc.subject.mesh | Kidney | pt |
dc.subject.mesh | Pyrazines | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Rats, Zucker | pt |
dc.subject.mesh | Sitagliptin Phosphate | pt |
dc.subject.mesh | Triazoles | pt |
dc.subject.mesh | Tumor Necrosis Factor-alpha | pt |
dc.title | Sitagliptin prevents inflammation and apoptotic cell death in the kidney of type 2 diabetic animals | pt |
dc.type | article | - |
degois.publication.firstPage | 538737 | pt |
degois.publication.lastPage | 15 | pt |
degois.publication.title | Mediators of Inflammation | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2014/538737 | pt |
degois.publication.volume | 2014 | pt |
dc.date.embargo | 2014-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.openairetype | article | - |
item.languageiso639-1 | en | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0001-7828-2296 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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Sitagliptin-prevents-inflammation-and-apoptotic-cell-death-in-the-kidney-of-type-2-diabetic-animalsMediators-of-Inflammation.pdf | 3.32 MB | Adobe PDF | View/Open |
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