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|Title:||Ultrasensitive gold micro-structured electrodes enabling the detection of extra-cellular long-lasting potentials in astrocytes populations||Authors:||Mestre, Ana L. G.
Inácio, Pedro M. C.
Lourenço, Ana S.
Cristiano, Maria L. S.
Medeiros, Maria C. R.
Araújo, Inês M.
Gomes, Henrique L.
|Issue Date:||27-Oct-2017||Publisher:||Springer Nature||Project:||project “Implantable organic devices for advanced therapies” (INNOVATE), PTDC/EEI-AUT/5442/2014)
Instituto de Telecomunicações, UID/Multi/04326/2013
Associated Laboratory – Institute of Nanoscience and Nanotechnology (POCI-01-0145-FEDER-016623)
|Serial title, monograph or event:||Scientific Reports||Volume:||7||Issue:||1||Abstract:||Ultra-sensitive electrodes for extracellular recordings were fabricated and electrically characterized. A signal detection limit defined by a noise level of 0.3-0.4 μV for a bandwidth of 12.5 Hz was achieved. To obtain this high sensitivity, large area (4 mm2) electrodes were used. The electrode surface is also micro-structured with an array of gold mushroom-like shapes to further enhance the active area. In comparison with a flat gold surface, the micro-structured surface increases the capacitance of the electrode/electrolyte interface by 54%. The electrode low impedance and low noise enable the detection of weak and low frequency quasi-periodic signals produced by astrocytes populations that thus far had remained inaccessible using conventional extracellular electrodes. Signals with 5 μV in amplitude and lasting for 5-10 s were measured, with a peak-to-peak signal-to-noise ratio of 16. The electrodes and the methodology developed here can be used as an ultrasensitive electrophysiological tool to reveal the synchronization dynamics of ultra-slow ionic signalling between non-electrogenic cells.||URI:||https://hdl.handle.net/10316/108387||ISSN:||2045-2322||DOI:||10.1038/s41598-017-14697-y||Rights:||openAccess|
|Appears in Collections:||FCTUC Eng.Electrotécnica - Artigos em Revistas Internacionais|
I&D IT - Artigos em Revistas Internacionais
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