Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106963
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Figueiredo, Pedro | - |
dc.contributor.author | Almeida, Beatriz C. | - |
dc.contributor.author | Carvalho, Alexandra T. P. | - |
dc.date.accessioned | 2023-05-04T11:06:09Z | - |
dc.date.available | 2023-05-04T11:06:09Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2296-889X | pt |
dc.identifier.uri | https://hdl.handle.net/10316/106963 | - |
dc.description.abstract | Biodegradable polymers, obtained via chemical synthesis, are currently employed in a wide range of biomedical applications. However, enzymatic polymerization is an attractive alternative because it is more sustainable and safer. Many lipases can be employed in ring-opening polymerization (ROP) of biodegradable polymers. Nevertheless, the harsh conditions required in industrial context are not always compatible with their enzymatic activity. In this work, we have studied a thermophilic carboxylesterase and the commonly used Lipase B from Candida antarctica (CaLB) for tailored synthesis of amphiphilic polyesters for biomedical applications. We have conducted Molecular Dynamics (MD) and Quantum Mechanics/Molecular Mechanics (QM/MM) MD simulations of the synthesis of Polycaprolactone-Polyethylene Glycol (PCL-PEG) model co-polymers. Our insights about the reaction mechanisms are important for the design of customized enzymes capable to synthesize different polyesters for biomedical applications. | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers Media S.A. | pt |
dc.relation | project[s] MITPortugal (MIT-EXPL/ISF/0021/2017) | pt |
dc.relation | grant IF/01272/2015 | pt |
dc.relation | UID/NEU/04539/2019 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | MD calculations | pt |
dc.subject | QM/MM MD simulations | pt |
dc.subject | PCL-PEG co-polymers | pt |
dc.subject | biodegradable polymers | pt |
dc.subject | ROP | pt |
dc.title | Enzymatic Polymerization of PCL-PEG Co-polymers for Biomedical Applications | pt |
dc.type | article | - |
degois.publication.firstPage | 109 | pt |
degois.publication.title | Frontiers in Molecular Biosciences | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fmolb.2019.00109 | pt |
degois.publication.volume | 6 | pt |
dc.date.embargo | 2019-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | CNC. IBILI | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0002-1243-0265 | - |
crisitem.author.orcid | 0000-0003-2827-5527 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Enzymatic polymerization of pcl-peg co-polymers for biomedical applications.pdf | 1.09 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
10
checked on Sep 16, 2024
WEB OF SCIENCETM
Citations
11
checked on Sep 2, 2024
Page view(s)
58
checked on Sep 24, 2024
Download(s)
15
checked on Sep 24, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License