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https://hdl.handle.net/10316/106773
Título: | PCL enzymatic hydrolysis: a mechanistic study | Autor: | Almeida, Beatriz C. Figueiredo, Pedro Carvalho, Alexandra T. P. |
Palavras-chave: | Quantitative Biology - Biomolecules; Quantitative Biology - Biomolecules | Data: | 27-Mar-2019 | Editora: | American Chemical Society | Projeto: | FCT - project MIT-Portugal (MIT-EXPL/ISF/0021/2017) FCT - grant IF/01272/2015 |
Título da revista, periódico, livro ou evento: | ACS Omega | Volume: | 4 | Número: | 4 | Resumo: | Accumulation of plastic waste is a major environmental problem. Enzymes, particularly esterases, play an important role in the biodegradation of polyesters. These enzymes are usually only active on aliphatic polyesters, but a few have showed catalytic activity for semi-aromatic polyesters. Due to the importance of these processes, an atomic level characterization of how common polyesters are degraded by esterases is necessary. Hereby, we present a Molecular dynamics (MD) and Quantum Mechanics/Molecular Mechanics (QM/MM) MD study of the hydrolysis of a model of polycaprolactone (PCL), one of the most widely used biomaterials, by the thermophilic esterase from the archaeon Archaeoglobus fulgidus (AfEST). This enzyme is particularly interesting because it can withstand temperatures well above the glass transition of many polyesters. Our insights about the reaction mechanism are important for the design of customized enzymes able to degrade different synthetic polyesters. | URI: | https://hdl.handle.net/10316/106773 | ISSN: | 2470-1343 2470-1343 |
DOI: | 10.1021/acsomega.9b00345 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Polycaprolactone-Enzymatic-Hydrolysis-A-Mechanistic-StudyACS-Omega.pdf | 3.23 MB | Adobe PDF | Ver/Abrir |
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