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Título: | Extracellular Vesicles Physiological Role and the Particular Case of Disease-Spreading Mechanisms in Polyglutamine Diseases | Autor: | Moreira, Ricardo Mendonça, Liliana Simões Almeida, Luís Pereira de |
Palavras-chave: | extracellular vesicles;; disease spreading;; neurodegenerative diseases;; polyglutamine diseases;; vehicle;; biomarker | Data: | 13-Nov-2021 | Editora: | MDPI | Projeto: | CENTRO-01- 0145-FEDER-000008 UIDB/04539/2020 POCI-01-0145-FEDER-030737 PTDC/BTM-ORG/30737/2017 CEECIND/04242/2017 PhD Scholarship 2020.04751.BD National Ataxia Foundation French Muscular Dystrophy Association (AFM-Téléthon) Trampoline Grant #20126 Richard Chin and Lily Lock Machado–Joseph Disease Research Fund JPND project SynSpread |
Título da revista, periódico, livro ou evento: | International Journal of Molecular Sciences | Volume: | 22 | Número: | 22 | Resumo: | Recent research demonstrated pathological spreading of the disease-causing proteins from one focal point across other brain regions for some neurodegenerative diseases, such as Parkinson's and Alzheimer's disease. Spreading mediated by extracellular vesicles is one of the proposed disease-spreading mechanisms. Extracellular vesicles are cell membrane-derived vesicles, used by cells for cell-to-cell communication and excretion of toxic components. Importantly, extracellular vesicles carrying pathological molecules, when internalized by "healthy" cells, may trigger pathological pathways and, consequently, promote disease spreading to neighboring cells. Polyglutamine diseases are a group of genetic neurodegenerative disorders characterized by the accumulation of mutant misfolded proteins carrying an expanded tract of glutamines, including Huntington's and Machado-Joseph disease. The pathological spread of the misfolded proteins or the corresponding mutant mRNA has been explored. The understanding of the disease-spreading mechanism that plays a key role in the pathology progression of these diseases can result in the development of effective therapeutic approaches to stop disease progression, arresting the spread of the toxic components and disease aggravation. Therefore, the present review's main focus is the disease-spreading mechanisms with emphasis on polyglutamine diseases and the putative role played by extracellular vesicles in this process. | URI: | https://hdl.handle.net/10316/104803 | ISSN: | 1422-0067 | DOI: | 10.3390/ijms222212288 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais |
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Extracellular-vesicles-physiological-role-and-the-particular-case-of-diseasespreading-mechanisms-in-polyglutamine-diseasesInternational-Journal-of-Molecular-Sciences.pdf | 2.05 MB | Adobe PDF | Ver/Abrir |
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