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Title: Advances in the automated synthesis of 6-[18F]Fluoro-L-DOPA
Authors: Neves, Ângela C. B. 
Hrynchak, Ivanna 
Fonseca, Inês 
Alves, Vítor H. P. 
Pereira, Mariette M. 
Falcão, Amílcar 
Abrunhosa, Antero J. 
Keywords: 6-[18F]FDOPA; Automated synthesis; Nonproteinogenic amino acid; PET; Radiochemistry
Issue Date: 10-Mar-2021
Publisher: Springer Nature
Project: POCI- 01-0247-FEDER-023474 
PhD grant PD/BDE/135132/2017 
Serial title, monograph or event: EJNMMI Radiopharmacy and Chemistry
Volume: 6
Issue: 1
Abstract: The neurotracer 6-[18F] FDOPA has been, for many years, a powerful tool in PET imaging of neuropsychiatric diseases, movement disorders and brain malignancies. More recently, it also demonstrated good results in the diagnosis of other malignancies such as neuroendocrine tumours, pheochromocytoma or pancreatic adenocarcinoma.The multiple clinical applications of this tracer fostered a very strong interest in the development of new and improved methods for its radiosynthesis. The no-carrier-added nucleophilic 18F-fluorination process has gained increasing attention, in recent years, due to the high molar activities obtained, when compared with the other methods although the radiochemical yield remains low (17-30%). This led to the development of several nucleophilic synthetic processes in order to obtain the product with molar activity, radiochemical yield and enantiomeric purity suitable for human PET studies.Automation of the synthetic processes is crucial for routine clinical use and compliance with GMP requirements. Nevertheless, the complexity of the synthesis makes the production challenging, increasing the chance of failure in routine production. Thus, for large-scale clinical application and wider use of this radiopharmaceutical, progress in the automation of this complex radiosynthesis is of critical importance.This review summarizes the most recent developments of 6-[18F]FDOPA radiosynthesis and discusses the key issues regarding its automation for routine clinical use.
ISSN: 2365-421X
DOI: 10.1186/s41181-021-00126-z
Rights: openAccess
Appears in Collections:I&D ICNAS - Artigos em Revistas Internacionais
I&D CQC - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais

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