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https://hdl.handle.net/10316/103765
Title: | Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma | Authors: | Lopes, Joana Ferreira-Gonçalves, Tânia Figueiredo, Isabel V. Rodrigues, Cecília M. P. Ferreira, Hugo Ferreira, David Viana, Ana S. Faísca, Pedro Gaspar, Maria Manuela Coelho, João M. P. Silva, Catarina Oliveira Reis, Catarina Pinto |
Keywords: | multifunctional nanoparticles; gold nanoparticles; targeted therapy; photothermal therapy; superficial tumors; melanoma; experimental models | Issue Date: | 30-Mar-2021 | Publisher: | MDPI AG | Project: | PTDC/BBB-BMC/0611/2012 UIDB/00645/2020 UIDB/04138/2020 UIDP/04138/2020 SFRH/BD/148044/2019 SFRH/BD/147306/2019 |
Serial title, monograph or event: | Biomolecules | Volume: | 11 | Issue: | 4 | Abstract: | The global impact of cancer emphasizes the importance of developing innovative, effective and minimally invasive therapies. In the context of superficial cancers, the development of a multifunctional nanoparticle-based system and its in vitro and in vivo safety and efficacy characterization are, herein, proposed as a proof-of-concept. This multifunctional system consists of gold nanoparticles coated with hyaluronic and oleic acids, and functionalized with epidermal growth factor for greater specificity towards cutaneous melanoma cells. This nanoparticle system is activated by a near-infrared laser. The characterization of this nanoparticle system included several phases, with in vitro assays being firstly performed to assess the safety of gold nanoparticles without laser irradiation. Then, hairless immunocompromised mice were selected for a xenograft model upon inoculation of A375 human melanoma cells. Treatment with near-infrared laser irradiation for five minutes combined with in situ administration of the nanoparticles showed a tumor volume reduction of approximately 80% and, in some cases, led to the formation of several necrotic foci, observed histologically. No significant skin erythema at the irradiation zone was verified, nor other harmful effects on the excised organs. In conclusion, these assays suggest that this system is safe and shows promising results for the treatment of superficial melanoma. | URI: | https://hdl.handle.net/10316/103765 | ISSN: | 2218-273X | DOI: | 10.3390/biom11040511 | Rights: | openAccess |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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