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Title: Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions
Authors: Magalhães, João Duarte
Fão, Lígia 
Vilaça, Rita 
Cardoso, Sandra Morais 
Rego, A. Cristina 
Keywords: neurodegenerative disorders; autophagy; mitophagy mitochondrial dysfunction; mutant proteins; therapeutic strategies
Issue Date: 5-Nov-2021
Publisher: MDPI
Project: CENTRO-01-0145-FEDER-000012-HealthyAging 2020 
POCI-01-0145-FEDER- 030712 
Serial title, monograph or event: Biomedicines
Volume: 9
Issue: 11
Abstract: Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunction in the etiology of Alzheimer's, Parkinson's, and Huntington's diseases. Macroautophagy has been implicated in the degradation of different protein aggregates such as Aβ, tau, alpha-synuclein (α-syn), and mutant huntingtin (mHtt) and in the clearance of dysfunctional mitochondria. Taking these into consideration, targeting autophagy might represent an effective therapeutic strategy to eliminate protein aggregates and to improve mitochondrial function in these disorders. The present review describes our current understanding on the role of macroautophagy in neurodegenerative disorders and focuses on possible strategies for its therapeutic modulation.
ISSN: 2227-9059
DOI: 10.3390/biomedicines9111625
Rights: openAccess
Appears in Collections:I&D CNC - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais

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