Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/103756
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dc.contributor.authorMartins-Marques, Tânia-
dc.date.accessioned2022-11-24T13:04:37Z-
dc.date.available2022-11-24T13:04:37Z-
dc.date.issued2021-09-15-
dc.identifier.issn2046-6390-
dc.identifier.urihttp://hdl.handle.net/10316/103756-
dc.description.abstractWell-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell-cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell-extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author.pt
dc.language.isoengpt
dc.publisherThe Company of Biologists Ltd.pt
dc.relationCENTRO-01-0145-FEDER-000012-N2323pt
dc.relationCENTRO-01-0145-FEDER-032179pt
dc.relationCENTRO-01-0145-FEDER-032414pt
dc.relationPOCI- 01-0145-FEDER-022122pt
dc.relationUIDB/04539/2020pt
dc.relationUIDP/04539/2020pt
dc.relationEuropean Cooperation in Science and Technology (COST) Action EUCARDIOPROTECTION CA16225pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectGap junctionspt
dc.subjectExtracellular vesiclespt
dc.subjectTunneling nanotubespt
dc.subjectCell-based therapiespt
dc.subjectMyocardial infarctionpt
dc.subjectCardiac hypertrophypt
dc.titleConnecting different heart diseases through intercellular communicationpt
dc.typearticlept
degois.publication.issue9pt
degois.publication.titleBiology Openpt
dc.peerreviewedyespt
dc.identifier.doi10.1242/bio.058777-
degois.publication.volume10pt
dc.date.embargo2021-09-15*
dc.identifier.pmid34494646-
uc.date.periodoEmbargo0pt
dc.identifier.eissn2046-6390-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.orcid0000-0001-5798-3923-
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D ICBR - Artigos em Revistas Internacionais
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This item is licensed under a Creative Commons License Creative Commons