Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/103756
Title: Connecting different heart diseases through intercellular communication
Authors: Martins-Marques, Tânia 
Keywords: Gap junctions; Extracellular vesicles; Tunneling nanotubes; Cell-based therapies; Myocardial infarction; Cardiac hypertrophy
Issue Date: 15-Sep-2021
Publisher: The Company of Biologists Ltd.
Project: CENTRO-01-0145-FEDER-000012-N2323 
CENTRO-01-0145-FEDER-032179 
CENTRO-01-0145-FEDER-032414 
POCI- 01-0145-FEDER-022122 
UIDB/04539/2020 
UIDP/04539/2020 
European Cooperation in Science and Technology (COST) Action EUCARDIOPROTECTION CA16225 
Serial title, monograph or event: Biology Open
Volume: 10
Issue: 9
Abstract: Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell-cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell-extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author.
URI: https://hdl.handle.net/10316/103756
ISSN: 2046-6390
DOI: 10.1242/bio.058777
Rights: openAccess
Appears in Collections:I&D ICBR - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais

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