Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/103454
Title: The Role of Glucosinolates from Cruciferous Vegetables (Brassicaceae) in Gastrointestinal Cancers: From Prevention to Therapeutics
Authors: Melim, Catarina 
Lauro, Maria R.
Pires, Isabel M.
Oliveira, Paulo J. 
Cabral, Célia 
Keywords: gastrointestinal tract; gastrointestinal cancers; cruciferous vegetables; glucosinolates; sulforaphane; stability; formulation
Issue Date: 14-Jan-2022
Publisher: MDPI
Project: PTDC/ASP-HOR/29152/2017 
POCI-01-0145-FEDER-029152 
UIDB/04539/2020 
UIDP/04539/2020 
COA/BRB/0019/2019 
Bowel Research UK (reference 000100009) 
University of Hull 
Serial title, monograph or event: Pharmaceutics
Volume: 14
Issue: 1
Abstract: The gastrointestinal (GI) tract is composed of rapidly renewing cells, which increase the likelihood of cancer. Colorectal cancer is one of the most frequently diagnosed GI cancers and currently stands in second place regarding cancer-related mortality. Unfortunately, the treatment of GI is limited, and few developments have occurred in the field over the years. With this in mind, new therapeutic strategies involving biologically active phytocompounds are being evaluated as anti-cancer agents. Vegetables such as broccoli, brussels sprouts, cabbage, cauliflower, and radish, all belonging to the Brassicaceae family, are high in dietary fibre, minerals, vitamins, carotenoids, polyphenols, and glucosinolates. The latter compound is a secondary metabolite characteristic of this family and, when biologically active, has demonstrated anti-cancer properties. This article reviews the literature regarding the potential of Cruciferous vegetables in the prevention and/or treatment of GI cancers and the relevance of appropriate compound formulations for improving the stability and bioaccessibility of the major Cruciferous compounds, with a particular focus on glucosinolates.
URI: https://hdl.handle.net/10316/103454
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics14010190
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais
I&D CIBB - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
I&D CFE - Artigos em Revistas Internacionais

Show full item record

SCOPUSTM   
Citations

21
checked on Mar 25, 2024

WEB OF SCIENCETM
Citations

21
checked on Mar 2, 2024

Page view(s)

68
checked on Mar 26, 2024

Download(s)

53
checked on Mar 26, 2024

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons