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Title: Understanding of Immune Escape Mechanisms and Advances in Cancer Immunotherapy
Authors: Aktar, Nasrin
Yueting, Chen
Abbas, Muhammad
Zafar, Hajra
Paiva-Santos, Ana Cláudia 
Zhang, Qin
Chen, Tingting
Ahmed, Moudud
Raza, Faisal
Zhou, Xiaohui
Issue Date: 2022
Project: National Natural Science Foundation of China (# 30973003; 30901993), 
Jiangsu Province’s Key Provincial Talents Program (# QNRC2016530) of China 
Riphah International University, Islamabad, Pakistan (Riphah-ORIC-21-22/FPS-51) 
Serial title, monograph or event: Journal of Oncology
Volume: 2022
Abstract: Tumor immune escape has emerged as the most significant barrier to cancer therapy. A thorough understanding of tumor immune escape therapy mechanisms is critical for further improving clinical treatment strategies. Currently, research indicates that combining several immunotherapies can boost antitumor efficacy and encourage T cells to play a more active part in the immune assault. To generate a more substantial therapeutic impact, it can establish an ideal tumor microenvironment (TME), encourage T cells to play a role, prevent T cell immune function reversal, and minimize tumor immune tolerance. In this review, we will examine the mechanisms of tumor immune escape and the limits of tumor immune escape therapy, focusing on the current development of immunotherapy based on tumor immune escape mechanisms. Individualized tumor treatment is becoming increasingly apparent as future treatment strategies. In addition, we forecast the future research direction of cancer and the clinical approach for cancer immunotherapy. It will serve as a better reference for researchers working in cancer therapy research.
ISSN: 1687-8450
DOI: 10.1155/2022/8901326
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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