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Title: The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders
Authors: Luís, João P. 
Simões, Carlos J. V. 
Brito, Rui M. M. 
Keywords: interleukin-1; interleukin-1 receptor type 1; neuroinflammation; CNS diseases; therapeutic target
Issue Date: 2-Feb-2022
Project: FCT - Ph.D. grant PD/BD/135292/2017 
FCT - UID/QUI/00313/2019 
Serial title, monograph or event: International Journal of Molecular Sciences
Volume: 23
Issue: 3
Abstract: The interleukin-1 receptor type 1 (IL-1R1) holds pivotal roles in the immune system, as it is positioned at the "epicenter" of the inflammatory signaling networks. Increased levels of the cytokine IL-1 are a recognized feature of the immune response in the central nervous system (CNS) during injury and disease, i.e., neuroinflammation. Despite IL-1/IL-1R1 signaling within the CNS having been the subject of several studies, the roles of IL-1R1 in the CNS cellular milieu still cause controversy. Without much doubt, however, the persistent activation of the IL-1/IL-1R1 signaling pathway is intimately linked with the pathogenesis of a plethora of CNS disease states, ranging from Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS), all the way to schizophrenia and prion diseases. Importantly, a growing body of evidence is showing that blocking IL-1R1 signaling via pharmacological or genetic means in different experimental models of said CNS diseases leads to reduced neuroinflammation and delayed disease progression. The aim of this paper is to review the recent progress in the study of the biological roles of IL-1R1, as well as to highlight key aspects that render IL-1R1 a promising target for the development of novel disease-modifying treatments for multiple CNS indications.
ISSN: 1422-0067
DOI: 10.3390/ijms23031731
Rights: openAccess
Appears in Collections:I&D CQC - Artigos em Revistas Internacionais

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