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Title: "MitoTea": Geranium robertianum L. decoctions decrease blood glucose levels and improve liver mitochondrial oxidative phosphorylation in diabetic Goto-Kakizaki rats
Authors: Santos, Maria Sancha 
Seiça, Raquel 
Sena, Cristina 
Nunes, Elsa 
Peixoto, Francisco
Ferreira, Fernanda M.
Keywords: Goto–Kakizaki (GK) rats; type 2 diabetes mellitus; Geranium robertianum L.,; Vaccinium myrtillus L.; herbal medicine; oxidative phosphorylation
Issue Date: 2010
Serial title, monograph or event: Acta Biochimica Polonica
Volume: 57
Issue: 4
Abstract: Several chemical compounds found in plant products have proven to possess beneficial properties, being currently pointed out due to their pharmacological potential in type 2 diabetes mellitus complications. In this context, we studied the effect of Geranium robertianum L. (herb Robert) leaf decoctions in Goto–Kakizaki (GK) rats, a model of type 2 diabetes. Our results showed that oral administration of G. robertianum leaf decoctions over a period of four weeks lowered the plasma glucose levels in diabetic rats. Furthermore, the treatment with G. robertianum extracts improved liver mitochondrial respiratory parameters (state 3, state 4 and FCCP-stimulated respiration) and increased oxidative phosphorylation efficiency.
ISSN: 1734-154X
DOI: 10.18388/abp.2010_2424
Rights: openAccess
Appears in Collections:I&D IBILI - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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