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Título: | Monoamine oxidase and semicarbazide-sensitive amine oxidase kinetic analysis in mesenteric arteries of patients with type 2 diabetes | Autor: | Nunes, S. F. Figueiredo, I. V. Pereira, João Lemos, E. T. Reis, F. Teixeira, F. Caramona, M. M. |
Palavras-chave: | Human mesenteric arteries; Monoamine oxidase; Semicarbazide-sensitive amine oxidase; Type 2 diabetes; Noradrenaline content | Data: | 2011 | Projeto: | FCT - SFRH/BD/2005 | Título da revista, periódico, livro ou evento: | Physiological Research | Volume: | 60 | Número: | 2 | Resumo: | Monoamine oxidase (MAO, type A and B) and semicarbazide-sensitive amine oxidase (SSAO) metabolize biogenic amines, however, the impact of these enzymes in arteries from patients with type 2 diabetes remains poorly understood. We investigated the kinetic parameters of the enzymes to establish putative correlations with noradrenaline (NA) content and patient age in human mesenteric arteries from type 2 diabetic patients. The kinetic parameters were evaluated by radiochemical assay and NA content by high-performance liquid chromatography (HPLC). The activity of MAO-A and SSAO in type 2 diabetic vascular tissues was significantly lower compared to the activity obtained in non-diabetic tissues. In the correlation between MAO-A (K(m)) and NA content, we found a positive correlation for both the diabetic and non-diabetic group, but no correlation was established for patient age. In both groups, MAO-B (V(max)) showed a negative correlation with age. The results show that MAO-A and SSAO activities and NA content of type 2 diabetic tissues are lower compared to the non-diabetic tissues, while MAO-B activity remained unchanged. These remarks suggest that MAO-A and SSAO may play an important role in vascular tissue as well as in the vascular pathophysiology of type 2 diabetes. | URI: | https://hdl.handle.net/10316/102755 | ISSN: | 1802-9973 0862-8408 |
DOI: | 10.33549/physiolres.931982 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais |
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Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase.pdf | 768.84 kB | Adobe PDF | Ver/Abrir |
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