Santana, Isabel
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Santana, Isabel
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Santana, Isabel J.
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Santana, Isabel
Santana, I.
Santana, I.
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UC Researcher
Biography
Maria Isabel Jacinto Santana graduated in Medicine at the University of Coimbra in 1984, completed is PhD in Neurology (Alzheimer's Disease) in 1999 and is Full Professor of Neurology at the Faculty of Medicine of the University of Coimbra and co-coordinator of the Neurosciences and Mental Health Group since 2019. She is the director of the Neurology Department at the Centro Hospitalar e Universitário de Coimbra, being head of the Memory/Dementia Clinic and the Neuropsychological Unit and coordinator of the Coimbra Center at the European Alzheimers disease Consortium (EADC). Her main areas of expertise are neurodegenerative diseases in both clinical practise and translational investigation, including 20 years of experience in clinical trials and is a member of the National Ethics Committee for Clinical Investigation (CEIC) since 2017. As an integrated Member of the Center for Neuroscience and Cell Biology (CNC-UC) and head of the clinical/translational research group "Biomarkers in Neuropsychiatric Disorders: from Molecules to Diagnosis and Intervention" of the Center for Innovative Biomedicine and Biotechnology. She participates and/or has participated as Principal investigator in 13 project(s) and as Researcher in 26 project(s) with competitive financial support, received 26 awards and/or honors, is author/co-author of over 250 papers (6492 citations/h factor: 41), 31 books/section(s) of books and of more than 500 oral presentations in national and/or international scientific meetings. She has supervised/co-supervised 10 PhD thesis and 51 MSc dissertations.
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Results 1-72 of 72 (Search time: 0.001 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | 20-Mar-2018 | Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive impairment | Baldeiras, Inês ; Santana, Isabel ; Leitão, Maria João ; Gens, Helena; Pascoal, Rui; Tábuas-Pereira, Miguel ; Beato-Coelho, José; Duro, Diana ; Almeida, Maria do Rosário ; Oliveira, Catarina Resende de | article | openAccess |
| 2 | 10-Dec-2020 | Alterações Emocionais na Doença de Pequenos Vasos Cerebrais Esporádica e CADASIL: Revisão da literatura e estudo exploratório | Santos, Irina Sofia Reis Gomes | masterThesis | openAccess |
| 3 | 30-May-2018 | Aphasia Rapid Test: Estudos de Tradução, Adaptação e Validação para a População Portuguesa | Tábuas-Pereira, Miguel ; Freitas, Sandra ; Beato-Coelho, José; Ribeiro, Joana; Parra, Joana; Martins, Cristina ; Silva, Miguel; Matos, Maria Assunção; Nogueira, Ana Rita; Silva, Fernando; Sargento-Freitas, João ; Cordeiro, Gustavo ; Cunha, Luís ; Santana, Isabel | article | openAccess |
| 4 | Sep-2012 | APOE e transformação hemorrágica após administração de alteplase em doentes com acidente vascular cerebral isquémico agudo | Pedrosa, Isabel Sofia de Sousa | masterThesis | openAccess |
| 5 | 3-Apr-2017 | Behavioral Symptoms in the Variants of Primary Progressive Aphasia | Martins, Marta Oliveira | masterThesis | embargoedAccess |
| 6 | 17-Jul-2014 | Características clínicas de doentes e portadores da expansão hexanucleotídica no gene C9ORF72 | Pires, José Guilherme Neri Miranda | masterThesis | openAccess |
| 7 | 30-Jan-2020 | Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia | Llorens, Franc; Hermann, Peter; Villar-Piqué, Anna; Diaz-Lucena, Daniela; Nägga, Katarina; Hansson, Oskar; Santana, Isabel ; Schmitz, Matthias; Schmidt, Christian; Varges, Daniela; Goebel, Stefan; Dumurgier, Julien; Zetterberg, Henrik; Blennow, Kaj; Paquet, Claire; Baldeiras, Inês ; Ferrer, Isidro; Zerr, Inga | article | openAccess |
| 8 | 2016 | Clinical validation of Alzheimer's disease assessment scale - cognitive sub-scale (ADAS-cog) - for the portuguese population | Nogueira, Joana | masterThesis | openAccess |
| 9 | 23-Nov-2019 | Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer's disease | Leitão, Maria João ; Spínola, Anuschka da Silva ; Santana, Isabel ; Olmedo, Veronica; Nadal, Alicia; Le Bastard, Nathalie; Baldeiras, Inês | article | openAccess |
| 10 | Nov-2018 | Congenital heart disease: New challenges | Santana, Isabel | article | openAccess |
| 11 | 28-Oct-2019 | Contributos para o estudo do Funcionamento Cognitivo e Emocional na Doença de Pequenos Vasos Cerebrais | António, Inês Guedes Santos Patrício | masterThesis | openAccess |
| 12 | Mar-2013 | Correlação entre localização e atividade epileptogénica : comparação entre epilepsias focais por tumores benignos e displasias corticais focais | Brás, Ana Catarina Branquinho | masterThesis | openAccess |
| 13 | 2018 | Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of Aβ species | Oliveira, Francisco ; Leuzy, Antoine; Castelhano, J. ; Chiotis, Konstantinos; Hasselbalch, Steen Gregers; Rinne, Juha; Mendonça, Alexandre de ; Otto, Markus; Lleó, Alberto ; Santana, Isabel ; Johansson, Jarkko; Anderl-Straub, Sarah; Arnim, Christine; Beer, Ambros; Blesa, Rafael ; Fortea, Juan; Sanna-Kaisa, Herukka; Portelius, Erik; Pannee, Josef; Zetterberg, Henrik; Blennow, Kaj; Moreira, Ana P. ; Abrunhosa, Antero ; Nordberg, Agneta; Castelo-Branco, Miguel | article | openAccess |
| 14 | 2011 | Defeito cognitivo ligeiro e doença de Alzheimer : conversão ou progressão? | Carmo, João Filipe Guia Alves do | masterThesis | openAccess |
| 15 | 2010 | Defeito cognitivo ligeiro e psicopatologia | Gonçalves, José Alves Grilo | masterThesis | openAccess |
| 16 | 2015 | Defeito cognitivo ligeiro:análise comparativa dos resultados nos testes de recordação selectiva livre e guiada (TRSLG), memória lógica (ML, WMS-III) e memória visuo-espacial (TBMV-VR) | Bernardino, Sandra Isabel Teixeira | masterThesis | openAccess |
| 17 | 30-Oct-2013 | Desempenho cognitivo não credível no declínio cognitivo ligeiro: estudos com o Test of Memory Malingering (TOMM) e o Rey-15Item Memory Test (Rey15-IMT) | Jesus, Sara Adriana Silva de | masterThesis | openAccess |
| 18 | Feb-2012 | Determinação do estado redox do líquido céfalo-raquídeo na doença de Alzheimer | Sardo, Ana Isabel Franganito | masterThesis | openAccess |
| 19 | 2011 | Dieta mediterrânica e doença de Alzheimer | Pereira, Carolina Duarte | masterThesis | openAccess |
| 20 | Mar-2012 | Displasia cortical focal e epilepsia : comparação de EEG interictal e ictal com a localização da lesão | Patrocínio, João Pedro Silva Lima | masterThesis | openAccess |
| 21 | 2016 | Domain-specific functional organization: neurocognitive characterization of a case of hemi-prosopometamorphopsia | Freixo, Andreia | masterThesis | openAccess |
| 22 | 23-Oct-2017 | A Double Dissociation between Acting on and Knowing How to Act on Tools | Valério, Daniela Filipa Codinha | masterThesis | closedAccess |
| 23 | 28-Nov-2018 | Early Transcranial Color-Coded Sonography as a predictor of Hemorrhagic Transformation after Thrombectomy | Costa, André Jorge Assunção | masterThesis | embargoedAccess |
| 24 | 2011 | Envelhecimento e défice cognitivo : estudos de adaptação, validação e normalização do Montreal Cognitive Assessment (MoCA) | Freitas, Sandra | doctoralThesis | openAccess |
| 25 | 2015 | Epidemiologia da Demência e da Doença de Alzheimer em Portugal: Estimativas da Prevalência e dos Encargos Financeiros com a Medicação | Santana, Isabel ; Farinha, Filipa ; Freitas, Sandra ; Rodrigues, Vítor ; Carvalho, Álvaro | article | openAccess |
| 26 | Mar-2010 | Epidemiologia da demência em Portugal | Farinha, Filipa Margarida Cardoso | masterThesis | openAccess |
| 27 | 5-Jan-2019 | Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer's disease | Baldeiras, Inês ; Santana, Isabel ; Leitão, Maria João ; Vieira, Daniela ; Duro, Diana; Mroczko, Barbara; Kornhuber, Johannes; Lewczuk, Piotr | article | openAccess |
| 28 | 2017 | Escala de Avaliação da Doença de Alzheimer – Subescala cognitiva (ADAS-Cog): Dados normativo para a população portuguesa | Nogueira, Joana ; Freitas, Sandra ; Duro, Diana ; Tábuas-Pereira, Miguel ; Guerreiro, Manuela ; Almeida, Jorge ; Santana, Isabel | article | openAccess |
| 29 | Mar-2012 | Estudo da personalidade e de sintomas psicopatológicos na epilepsia de lobo temporal por esclerose mesial | Andrade, Mariana Lacerda Moreira de Noronha e | masterThesis | openAccess |
| 30 | 2012 | Estudo de validação da versão portuguesa da Escala de Avaliação da Incapacidade Funcional na Demência (Disability Assessment for Dementia - DAD) | Galhardo, Joana Rita Leonardo | masterThesis | openAccess |
| 31 | 2010 | Estudo de validação do Teste de Recordação Selectiva de Buschke – Buschke Selective Reminding Test | Afonso, Ana Cristina de Sousa Faria | workingPaper | openAccess |
| 32 | Jan-2016 | Estudos de adaptação e aplicação de uma Escala de Gravidade da Afasia de causa vascular | Silva, Miguel Neves Correia da | masterThesis | openAccess |
| 33 | 31-Oct-2014 | Estudos de validação do Montreal Cognitive Assessment (MoCA) na esclerose múltipla: análise da equivalência das versões alternativas 2 e 3 e exploração do perfil de desempenho cognitivo | Santiago, Joana Sofia Marques | masterThesis | openAccess |
| 34 | 28-Nov-2019 | Evaluation of Human Cerebrospinal Fluid Malate Dehydrogenase 1 as a Marker in Genetic Prion Disease Patients | Zerr, Inga; Villar-Piqué, Anna; Schmitz, Vanda Edit; Poleggi, Anna; Pocchiari, Maurizio; Sánchez-Valle, Raquel ; Calero, Miguel; Calero, Olga; Baldeiras, Inês ; Santana, Isabel ; Kovacs, Gabor G.; Llorens, Franc; Schmitz, Matthias | article | openAccess |
| 35 | 11-Aug-2020 | Face-Specific Perceptual Distortions Reveal A View- and Orientation-Independent Face Template | Almeida, Jorge ; Freixo, Andreia ; Tábuas-Pereira, Miguel ; Herald, Sarah B.; Valério, Daniela ; Schu, Guilherme ; Duro, Diana ; Cunha, Gil ; Bukhari, Qasim; Duchaine, Brad; Santana, Isabel | article | openAccess |
| 36 | 2010 | Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP | Guerreiro, Rita João ; Baquero, Miquel ; Blesa, Rafael ; Boada, Mercè ; Brás, José Miguel ; Bullido, Maria. J. ; Calado, Ana ; Crook, Richard ; Ferreira, Carla; Frank, Ana ; Gómez-Isla, Teresa ; Hernández, Isabel ; Lleó, Alberto ; Machado, Álvaro ; Martínez- Lage, Pablo ; Masdeu, José ; Molina-Porcel, Laura ; Molinuevo, José L. ; Pastor, Pau ; Pérez-Tur, Jordi ; Relvas, Rute ; Oliveira, Catarina Resende ; Ribeiro, Maria Helena ; Rogaeva, Ekaterina ; Sá, Alfredo ; Samaranch, Lluís ; Sánchez-Valle, Raquel ; Santana, Isabel ; Tàrraga, Lluís ; Valdivieso, Fernando ; Singleton, Andrew ; Hardy, John ; Clarimón, Jordi | article | openAccess |
| 37 | 3-Mar-2010 | Genetic Variability in CLU and Its Association with Alzheimer's Disease | Guerreiro, Rita J. ; Beck, John ; Gibbs, J. Raphael ; Santana, Isabel ; Rossor, Martin N. ; Schott, Jonathan M. ; Nalls, Michael A. ; Ribeiro, Helena ; Santiago, Beatriz ; Fox, Nick C. ; Oliveira, Catarina ; Collinge, John ; Mead, Simon ; Singleton, Andrew ; Hardy, John | article | openAccess |
| 38 | May-2011 | Glaucoma e doença de Alzheimer | Brito, Sergio Filipe Seco da Silva | masterThesis | openAccess |
| 39 | 6-Mar-2019 | Impact of vitamin D in patients with epilepsy | Saraiva, Ana Margarida Rajão | masterThesis | embargoedAccess |
| 40 | 17-Nov-2020 | Increased C-X-C Motif Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis | Andrés-Benito, Pol; Povedano, Mònica; Domínguez, Raúl; Marco, Carla; Colomina, Maria J.; López-Pérez, Óscar; Santana, Isabel ; Baldeiras, Inês ; Martínez-Yelámos, Sergio; Zerr, Inga; Llorens, Franc; Fernández-Irigoyen, Joaquín; Santamaría, Enrique; Ferrer, Isidro | article | openAccess |
| 41 | 25-Oct-2019 | Lower CSF Amyloid-Beta1-42 Predicts a Higher Mortality Rate in Frontotemporal Dementia | Vieira, Daniela ; Durães, João; Baldeiras, Inês; Santiago, Beatriz ; Duro, Diana; Lima, Marisa ; Leitão, Maria João ; Tábuas-Pereira, Miguel ; Santana, Isabel | article | openAccess |
| 42 | Mar-2012 | A metamemória na progressão do défice cognitivo ligeiro para a doença de Alzheimer | Lopes, Lisete Cachinho | masterThesis | openAccess |
| 43 | 2016 | MicroRNA deregulation and chemotaxis and phagocytosis impairment in Alzheimer's disease | Guedes, Joana R. ; Santana, Isabel ; Cunha, Catarina ; Duro, Diana ; Almeida, Maria R. ; Cardoso, Ana M. ; Lima, Maria C. Pedroso de ; Cardoso, Ana L. | article | openAccess |
| 44 | Apr-2016 | Mini-mental state examination: Avaliação dos novos dados normativos no rastreio e diagnóstico do défice cognitivo | Santana, Isabel ; Duro, Diana ; Lemos, Raquel; Costa, Vanessa ; Pereira, Miguel; Simões, Mário R. ; Freitas, Sandra | article | openAccess |
| 45 | 2012 | Mitochondrial DNA involvement in frontotemporal lobar degeneration : analysis of sequence variants in MTND genes | Fernandes, Ana Sofia Cleto | masterThesis | openAccess |
| 46 | May-2013 | Mitochondrial DNA variants in complex V coding genes contributing to frontotemporal lobar degeration | Abrantes, João Paulo Fernandes | masterThesis | openAccess |
| 47 | 2018 | Montreal Cognitive Assessment (MoCA) as a screening test for cognitive dysfunction in Multiple Sclerosis | Freitas, Sandra ; Batista, Sónia ; Afonso, Ana, C. ; Simões, Mário Rodrigues ; Sousa, Lívia de ; Cunha, Luís ; Santana, Isabel | article | openAccess |
| 48 | 17-Jul-2014 | Montreal Cognitive Assessment (MoCA): estudo de validação no défice cognitivo ligeiro vascular | Ferreira, Paulo Ricardo Alves | masterThesis | openAccess |
| 49 | 2013 | Montreal Cognitive Assessment (MoCA): Validation study for Mild Cognitive Impairment and Alzheimer´s Disease | Freitas, Sandra ; Simões, Mário Rodrigues ; Alves, Lara ; Santana, Isabel | article | openAccess |
| 50 | 22-Dec-2017 | Neural correlates of theory of mind impairment in multiple sclerosis | Baptista, Sónia Raquel Marques | doctoralThesis | embargoedAccess (2 years) |
| 51 | 13-Dec-2018 | Obesity as a risk factor for Alzheimer's disease: the role of adiponectin | Letra, Liliana Rita Velindro | doctoralThesis | openAccess |
| 52 | Mar-2010 | Parassónias | Garcia, Ana Rita de Meira | masterThesis | openAccess |
| 53 | 19-Jul-2017 | Predicting progression of mild cognitive impairment to dementia using neuropsychological data: a supervised learning approach using time windows | Pereira, Telma; Lemos, Luís; Cardoso, Sandra; Silva, Dina; Rodrigues, Ana ; Santana, Isabel ; Mendonça, Alexandre de; Guerreiro, Manuela ; Madeira, Sara C. | article | openAccess |
| 54 | 2013 | Premorbid IQ influence on screening tests' scores in healthy patients and patients with cognitive impairment | Alves, Lara ; Simões, Mário Rodrigues ; Martins, Cristina ; Freitas, Sandra ; Santana, Isabel | article | openAccess |
| 55 | 30-May-2019 | Presurgical Evaluation of Memory Function in Epilepsy Patients | Gonçalves, Carolina Barreto Rodrigues | masterThesis | embargoedAccess |
| 56 | Mar-2012 | Processamento emocional :|binfluência de variáveis demográficas | Abreu, Ana Carolina Canteiro | masterThesis | openAccess |
| 57 | 31-Oct-2014 | Processamento emocional no defeito cognitivo ligeiro | Antunes, Bárbara Ruivo | masterThesis | openAccess |
| 58 | 25-Apr-2016 | Prognosis of Early-Onset vs. Late-Onset Mild Cognitive Impairment: Comparison of Conversion Rates and Its Predictors | Tábuas-Pereira, Miguel ; Baldeiras, Inês ; Duro, Diana ; Santiago, Beatriz ; Ribeiro, Maria Helena ; Leitão, Maria João ; Oliveira, Catarina ; Santana, Isabel | article | openAccess |
| 59 | 2014 | Psychometric properties of the Montreal Cognitive Assessment (MoCA): An analysis using the Rasch model | Freitas, Sandra ; Gerardo, Prieto ; Simões, Mário Rodrigues ; Santana, Isabel | article | openAccess |
| 60 | 19-Feb-2015 | Regulação genética do receptor 5-HT2A na Demência Frontotemporal | Luís, Daniela Filipa Ribeiro | doctoralThesis | embargoedAccess |
| 61 | 2019 | Retinal texture biomarkers may help to discriminate between Alzheimer's, Parkinson's, and healthy controls | Nunes, Ana ; Silva, Gilberto ; Duque, Cristina; Januário, Cristina ; Santana, Isabel ; Ambrósio, António ; Castelo-Branco, Miguel ; Bernardes, Rui | article | openAccess |
| 62 | 2015 | Scaling cognitive domains of the Montreal Cognitive Assessment (MoCA): An analysis using the Partial Credit Model | Freitas, Sandra ; Prieto, Gerardo ; Simões, Mário Rodrigues ; Santana, Isabel | article | openAccess |
| 63 | 2019 | Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC) | Chincarini, A.; Peira, E.; Morbelli, S.; Pardini, M.; Bauckneht, M.; Arbizu, J.; Castelo-Branco, Miguel ; Büsing, K. A.; de Mendonça, A.; Didic, M.; Dottorini, M.; Engelborghs, S.; Ferrarese, C.; Frisoni, G. B.; Garibotto, V.; Guedj, E.; Hausner, L.; Hugon, J.; Verhaeghe, J.; Mecocci, P.; Musarra, M.; Queneau, M.; Riverol, M.; Santana, Isabel ; Guerra, U. P.; Nobili, F. | article | openAccess |
| 64 | 2013 | TeLPI Performance in subjects with Mild Cognitive Impairment and Alzheimer`s Disease: A validation study | Alves, Lara ; Simões, Mário Rodrigues ; Martins, Cristina ; Freitas, Sandra ; Santana, Isabel | article | openAccess |
| 65 | 2018 | The Quadruple Helix-Based Innovation Model of Reference Sites for Active and Healthy Ageing in Europe: The Ageing@Coimbra Case Study | Malva, João O. ; Amado, Alda ; Rodrigues, Alexandra; Mota-Pinto, Anabela ; Cardoso, Ana F.; Teixeira, Ana M. ; Todo-Bom, Ana ; Devesa, António; Ambrósio, António ; Cunha, António L.; Gomes, Bárbara ; Dantas, Carina; Abreu, Cidalina ; Santana, Isabel ; Bousquet, Jean ; Apóstolo, João ; Santos, Lúcia; Meneses de Almeida, Lúcio; Illario, Maddalena; Veríssimo, Rafaela ; Rodrigues, Vitor ; Veríssimo, Manuel T. | article | openAccess |
| 66 | 2015 | The relevance of sociodemographic and health variables on MMSE normative data | Freitas, Sandra ; Simões, Mário Rodrigues ; Alves, Lara ; Santana, Isabel | article | openAccess |
| 67 | 2020 | The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid β Load in Early Alzheimer's Disease | Jorge, Lília; Canário, Nádia; Martins, Ricardo ; Santiago, Beatriz ; Santana, Isabel ; Quental, Hugo ; Ambrósio, Francisco ; Bernardes, Rui ; Castelo-Branco, Miguel | article | openAccess |
| 68 | 20-Sep-2018 | Toulouse-Piéron Cancellation Test: Validation and normalization studies in cognitive decline | Neves, Marisa Pedroso de Lima Marta | masterThesis | embargoedAccess |
| 69 | Oct-2014 | Validation studies of the clock drawing test in mild cognitive impairment | Carneiro, Diogo Fernando Reis | masterThesis | openAccess |
| 70 | 22-Mar-2016 | Verbal Memory and Visual Perception in early Alzheimer’s disease: Contribution of new diagnostic tools for new classification criteria | Oliveira, Raquel Maria Baptista Lemos Guerra de | doctoralThesis | openAccess |
| 71 | 30-Oct-2018 | Visuoconstructional impairment in Mild Cognitive Impairment: Diagnostic utility and predictive value in the progression to Alzheimer’s disease | Gerardo, Bianca Salguinho | masterThesis | openAccess |
| 72 | 2019 | White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study | Sudre, Carole H.; Bocchetta, Martina; Heller, Carolin; Convery, Rhian; Neason, Mollie; Moore, Katrina M.; Cash, David M.; Thomas, David L.; Woollacott, Ione O. C.; Foiani, Martha; Heslegrave, Amanda; Shafei, Rachelle; Greaves, Caroline; van Swieten, John; Moreno, Fermin; Sánchez-Valle, Raquel ; Borroni, Barbara; Laforce, Robert; Masellis, Mario; Tartaglia, Maria Carmela; Graff, Caroline; Galimberti, Daniela; Rowe, James B; Finger, Elizabeth; Synofzik, Matthis; Vandenberghe, Rik; de Mendonça, Alexandre; Tagliavini, Fabrizio ; Santana, Isabel ; Ducharme, Simon; Butler, Chris; Gerhard, Alex; Levin, Johannes; Danek, Adrian; Frisoni, Giovanni B; Sorbi, Sandro; Otto, Markus; Zetterberg, Henrik; Ourselin, Sebastien; Cardoso, M Jorge; Rohrer, Jonathan D. | article | openAccess |