Laranjinha, João
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Laranjinha, João
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Laranjinha, João
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Laranjinha, João
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UC Researcher
Biography
João Laranjinha is professor of Biochemistry and Molecular Biology at the Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. He graduated in Pharmaceutical Sciences (University of Coimbra) in 1984 and got a PhD in Biochemistry (University of Coimbra) in 1996. He did Postdoc studies with Enrique Cadenas in 1997-1998 at the Dept. Molecular Pharmacology and Toxicology, University Southern California, Los Angeles, USA. His research is focused on the functional impact of nitric oxide in the brain as a neurometabolic regulator and as a mediator of neurovascular coupling with impact in aging and neurodegeneration. He is also interested in dietary nitrite-driven regulatory processes, encompassing the non-enzymatic production of nitric oxide along the nitrate:nitrite:NO pathway. He has been awarded several prizes, including the Science and Humanity award by The Oxygen Club of California and is member of the editorial board of major journals in his area of research, including Redox Biology, Free Radical Biology and Medicine, Archives of Biochemistry and Biophysics, Free Radical Research and Biofactors. He has chaired the organizing and scientific committees of several international conferences, including the European (SFRRE 2007) and International (SFRRI 2018) meetings of the Society for Free Radical Research. He has been member of the council of the European Society for Neurochemistry and the European Society for Free Radical Research for several years and President of the Portuguese Biochemical Society (2014-18). Currently, he serves as member of the Advanced Courses Committee of FEBS and as the president of the General Assembly of the Portuguese Biochemical Society.
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Results 1-61 of 61 (Search time: 0.002 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | 2008 | 3,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning | Nunes, Carla ; Almeida, Leonor ; Laranjinha, João | article | openAccess |
| 2 | Sep-2015 | Ação de flavonoides na doença inflamatória intestinal | Jin, Luyi | other | openAccess |
| 3 | 2018 | Age-Dependent Impairment of Neurovascular and Neurometabolic Coupling in the Hippocampus | Lourenço, Cátia F. ; Ledo, Ana ; Caetano, Miguel ; Barbosa, Rui M. ; Laranjinha, João | article | openAccess |
| 4 | Jun-2014 | Alzheimer: diabetes tipo 3? | Almeida, Mariana Matos de | other | openAccess |
| 5 | 2003 | Antioxidant protection of low density lipoprotein by procyanidins: structure/activity relationships | Porto, Patrícia Andréia Leite da Silva ; Laranjinha, João António Nave ; Freitas, Victor Armando Pereira de | article | openAccess |
| 6 | 5-Dec-2012 | Biological role of nitrite and nitric oxide in the stomach: from diet to protein tyrosine with implications for gastric physiology | Rocha, Bárbara Silva | doctoralThesis | openAccess |
| 7 | 15-Jun-2013 | Biomimetic sensor based on hemin/carbon nanotubes/chitosan modified microelectrode for nitric oxide measurement in the brain | Santos, Ricardo M. ; Rodrigues, Marcelo S. ; Laranjinha, João ; Barbosa, Rui M. | article | openAccess |
| 8 | 1998 | Cholesteryl Ester Hydroperoxide Formation in Myoglobin-Catalyzed Low Density Lipoprotein Oxidation : Concerted Antioxidant Activity of Caffeic and p-Coumaric Acids with Ascorbate | Vieira, Otília ; Laranjinha, João ; Madeira, Vítor ; Almeida, Leonor | article | openAccess |
| 9 | 2000 | Citotoxicidade e sinalização em células endoteliais vasculares induzidas por lipoproteínas humanas (LDL) oxidadas: mecanismos de protecção por ácidos fenólicos da dieta | Vieira, Maria Otília Vitoriana | doctoralThesis | embargoedAccess |
| 10 | Nov-2005 | Concentration Dynamics of Nitric Oxide in Rat Hippocampal Slices | Ledo, Ana ; Barbosa, Rui M. ; Cadenas, Enrique ; Gerhardt, Greg ; Laranjinha, João | article | openAccess |
| 11 | 29-Nov-2005 | Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor | Ledo, Ana ; Barbosa, Rui M. ; Gerhardt, Greg A. ; Cadenas, Enrique ; Laranjinha, João | article | openAccess |
| 12 | 2006 | Detecção electroquímica de óxido nítrico em fatias de hipocampo de rato com micoeléctrodos de fibra de carbono | Ferreira, Nuno Ricardo Esteves | masterThesis | openAccess |
| 13 | Jul-2014 | Diabetes tipo 3: uma nova perspectiva sobre a doença de Alzheimer | Marques, João Gabriel de Oliveira | other | openAccess |
| 14 | 15-Nov-2007 | Dinâmica de concentração do óxido nítrico produzido no hipocampo de rato por activação de receptores do glutamato | Ledo, Ana Margarida da Cruz | doctoralThesis | openAccess |
| 15 | 26-Sep-2008 | Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro | Bem, Andreza Fabro de ; Farina, Marcelo ; Portella, Rafael de Lima ; Nogueira, Cristina Wayne ; Dinis, Teresa C. P. ; Laranjinha, João A. N. ; Almeida, Leonor M. ; Rocha, João Batista Teixeira | article | openAccess |
| 16 | Sep-2015 | Doença de Alzheimer e resistência à insulina | Tuca, Octavian | other | openAccess |
| 17 | 30-Sep-2022 | Dynamic changes of aerobic brain oxidative metabolism revealed by lactate and the redox modulation by nitrite | Dias, Cândida Marília das Neves | doctoralThesis | openAccess |
| 18 | 2005 | Electrochemical measurement of endogenously produced nitric oxide in brain slices using Nafion/o-phenylenediamine modified carbon fiber microelectrodes | Ferreira, Nuno R. ; Ledo, Ana ; Frade, João G. ; Gerhardt, Greg A. ; Laranjinha, João ; Barbosa, Rui M. | article | openAccess |
| 19 | 2-Mar-2023 | Epigenetic Modifications Induced by the Gut Microbiota May Result from What We Eat: Should We Talk about Precision Diet in Health and Disease? | Reva, Katerina; Laranjinha, João ; Rocha, Bárbara S. | article | openAccess |
| 20 | Oct-2017 | European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) | Egea, Javier; Fabregat, Isabel; Frapart, Yves M; Ghezzi, Pietro; Görlach, Agnes; Kietzmann, Thomas; Kubaichuk, Kateryna; Knaus, Ulla G.; Lopez, Manuela G.; Olaso-Gonzalez, Gloria; Petry, Andreas; Schulz, Rainer; Vina, Jose; Winyard, Paul; Abbas, Kahina; Ademowo, Opeyemi S.; Afonso, Catarina B.; Andreadou, Ioanna; Antelmann, Haike; Antunes, Fernando; Aslan, Mutay; Bachschmid, Markus M.; Barbosa, Rui M. ; Belousov, Vsevolod; Berndt, Carsten; Bernlohr, David; Bertrán, Esther; Bindoli, Alberto; Bottari, Serge P.; Brito, Paula M. ; Carrara, Guia; Casas, Ana I.; Chatzi, Afroditi; Chondrogianni, Niki; Conrad, Marcus; Cooke, Marcus S.; Costa, João G.; Cuadrado, Antonio; My-Chan Dang, Pham; De Smet, Barbara; Debelec-Butuner, Bilge; Dias, Irundika H K; Dunn, Joe Dan; Edson, Amanda J; El Assar, Mariam; El-Benna, Jamel; Ferdinandy, Péter; Fernandes, Ana S.; Fladmark, Kari E.; Förstermann, Ulrich; Giniatullin, Rashid; Giricz, Zoltán; Görbe, Anikó; Griffiths, Helen; Hampl, Vaclav; Hanf, Alina; Herget, Jan; Hernansanz-Agustín, Pablo; Hillion, Melanie; Huang, Jingjing; Ilikay, Serap; Jansen-Dürr, Pidder; Jaquet, Vincent; Joles, Jaap A; Kalyanaraman, Balaraman; Kaminskyy, Danylo; Karbaschi, Mahsa; Kleanthous, Marina; Klotz, Lars-Oliver; Korac, Bato; Korkmaz, Kemal Sami; Koziel, Rafal; Kračun, Damir; Krause, Karl-Heinz; Kren, Vladimir ; Krieg, Thomas; Laranjinha, João ; Lazou, Antigone; Li, Huige; Martínez-Ruiz, Antonio; Matsui, Reiko; McBean, Gethin J.; Meredith, Stuart P.; Messens, Joris; Miguel, Verónica; Mikhed, Yuliya; Milisav, Irina; Milković, Lidija; Miranda-Vizuete, Antonio; Mojović, Miloš; Monsalve, María; Mouthuy, Pierre-Alexis; Mulvey, John; Münzel, Thomas; Muzykantov, Vladimir; Nguyen, Isabel T. N.; Oelze, Matthias; Oliveira, Nuno G; Palmeira, Carlos M. ; Papaevgeniou, Nikoletta; Pavićević, Aleksandra; Pedre, Brandán; Peyrot, Fabienne; Phylactides, Marios; Pircalabioru, Gratiela G.; Pitt, Andrew R.; Poulsen, Henrik E.; Prieto, Ignacio; Rigobello, Maria Pia; Robledinos-Antón, Natalia; Rodríguez-Mañas, Leocadio; Rolo, Anabela P. ; Rousset, Francis; Ruskovska, Tatjana; Saraiva, Nuno ; Sasson, Shlomo; Schröder, Katrin; Semen, Khrystyna; Seredenina, Tamara; Shakirzyanova, Anastasia; Smith, Geoffrey L.; Soldati, Thierry; Sousa, Bebiana C.; Spickett, Corinne M.; Stancic, Ana; Stasia, Marie José; Steinbrenner, Holger; Stepanić, Višnja; Steven, Sebastian; Tokatlidis, Kostas; Tuncay, Erkan; Turan, Belma; Ursini, Fulvio; Vacek, Jan; Vajnerova, Olga; Valentová, Kateřina; Van Breusegem, Frank; Varisli, Lokman; Veal, Elizabeth A.; Yalçın, A Suha; Yelisyeyeva, Olha; Žarković, Neven; Zatloukalová, Martina; Zielonka, Jacek; Touyz, Rhian M.; Papapetropoulos, Andreas; Grune, Tilman; Lamas, Santiago; Schmidt, Harald H H W; Di Lisa, Fabio; Daiber, Andreas | article | openAccess |
| 21 | Aug-2021 | A High Fat/Cholesterol Diet Recapitulates Some Alzheimer's Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction | Mancini, Gianni; Dias, Cândida ; Lourenço, Cátia F. ; Laranjinha, João ; Bem, Andreza de; Ledo, Ana | article | openAccess |
| 22 | 2013 | High-Resolution Respirometry for Metabolic Profiling of Acute Rat Hippocampal Slices | Henriques, Tiago André Ferreira | masterThesis | openAccess |
| 23 | Dec-2013 | Human colon adenocarcinoma HT-29 cell: electrochemistry and nicotine stimulation | Oliveira, S. C. B. ; Santarino, I. B. ; Enache, T. A. ; Nunes, C. ; Laranjinha, J. ; Barbosa, R. M. ; Brett, A. M. Oliveira | article | openAccess |
| 24 | 2022 | In vivo hydrogen peroxide diffusivity in brain tissue supports volume signaling activity | Ledo, A. ; Fernandes, E. ; Salvador, A. ; Laranjinha, J. ; Barbosa, R. M. | article | openAccess |
| 25 | 2000 | Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their impact on plasma total antioxidant capacity in humans | Serafini, Mauro ; Laranjinha, João A. N. ; Almeida, Leonor M. ; Maiani, G. | article | openAccess |
| 26 | 24-Sep-2018 | Innovative pathways underlying the etiology and the therapeutics via modulation of the gut microbiota | Ribeiro, Ricardo Manuel Esteves | masterThesis | openAccess |
| 27 | 25-Sep-2020 | Internship report and thesis entitled “Diet, microbiota and epigenetics – a dynamic and adjustable triade to explore new treatment approaches” | Reva, Katerina | masterThesis | openAccess |
| 28 | 28-May-2008 | LDL Isolated from Plasma-Loaded Red Wine Procyanidins Resist Lipid Oxidation and Tocopherol Depletion | Lourenço, Cátia F. ; Gago, Bruno ; Barbosa, Rui M. ; Freitas, Víctor de ; Laranjinha, João | article | openAccess |
| 29 | 26-Sep-2017 | O microbiota e o ser humano | Queiroz, João Pedro Nunes | masterThesis | openAccess |
| 30 | 6-Nov-2017 | Microbiota-host interactions during antibiotic therapy: unveiling novel redox signaling pathways with impact on gut homeostasis | Rocha, Bárbara Silva | masterThesis | closedAccess |
| 31 | 28-Jul-2017 | Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays | Lourenço, Cátia F. ; Ledo, Ana ; Gerhardt, Greg A. ; Laranjinha, João ; Barbosa, Rui M. | article | openAccess |
| 32 | 2015 | Neurovascular and neurometabolic derailment in aging and Alzheimer's disease | Lourenço, Cátia F. ; Ledo, Ana ; Dias, Cândida ; Barbosa, Rui M. ; Laranjinha, João | article | openAccess |
| 33 | 2004 | Nitric oxide in brain: diffusion, targets and concentration dynamics in hippocampal subregions | Ledo, Ana ; Frade, João ; Barbosa, Rui M. ; Laranjinha, João | article | openAccess |
| 34 | 2012 | Nitric oxide inactivation mechanisms in the brain: role in bioenergetics and neurodegeneration | Santos, Ricardo M. ; Lourenço, Cátia F. ; Ledo, Ana ; Barbosa, Rui M. ; Laranjinha, João | article | openAccess |
| 35 | 2012 | Nitric oxide mediates neurovascular coupling in the brain effect of polyphenols in animal models of Alzheimer's disease | Fonseca, Ana rita de Jesus Alves da | masterThesis | openAccess |
| 36 | 2021 | Nitric Oxide Pathways in Neurovascular Coupling Under Normal and Stress Conditions in the Brain: Strategies to Rescue Aberrant Coupling and Improve Cerebral Blood Flow | Lourenço, Cátia F. ; Laranjinha, João | article | openAccess |
| 37 | Sep-2016 | Nutrigenómica e qualidade de vida : funções e eficácia de moduladores de NRF2 presentes em suplementos da dieta | Oliveira, Luís Francisco Lourenço Vaz de | other | openAccess |
| 38 | Jul-2014 | Obesidade e diabetes: o papel das citocinas do tecido adiposo | Moura, Pedro Miguel Cruz Henriques | other | openAccess |
| 39 | 2002 | Oxidation of DOPAC by nitric oxide: effect of superoxide dismutase | Laranjinha, João ; Cadenas, Enrique | article | openAccess |
| 40 | 26-Jun-2019 | Pathophysiology of Doxorubicin Cardiotoxicity: From Mitochondrial Homeostasis to Biological Clocks | Ferreira, Luciana Carolina Lopes | doctoralThesis | embargoedAccess |
| 41 | 2008 | The potent vasodilator ethyl nitrite is formed upon reaction of nitrite and ethanol under gastric conditions | Gago, Bruno ; Nyström, Thomas ; Cavaleiro, Carlos ; Rocha, Bárbara S. ; Barbosa, Rui M. ; Laranjinha, João ; Lundberg, Jon O. | article | openAccess |
| 42 | 1996 | Pressão oxidativa em lipoproteínas humanas de baixa densidade (LDL): Mecanismos de antioxidação por ácidos fenólicos da dieta | Laranjinha, João António Nave | doctoralThesis | embargoedAccess |
| 43 | Dec-1996 | Rapid isolation of low density lipoproteins in a concentrated fraction free from water-soluble plasma antioxidants | Vieira, Otília V. ; Laranjinha, João A. ; Madeira, Vítor M. ; Almeida, Leonor M. | article | openAccess |
| 44 | 15-Sep-2008 | Real-time change of nitric oxide in rat hippocampal slices and astrocytic glutathione release via glutamate-dependent pathways | Frade, João Gonçalo Leal de Oliveira e Silva | doctoralThesis | openAccess |
| 45 | 2007 | Red wine-dependent reduction of nitrite to nitric oxide in the stomach | Gago, Bruno ; Lundberg, Jon O. ; Barbosa, Rui M. ; Laranjinha, João | article | openAccess |
| 46 | 1999 | Redox Cycles of Caffeic Acid, alpha-Tocopherol, and Ascorbate: Implications for Protection of Low-Density Lipoproteins Against Oxidation | Laranjinha, João ; Cadenas, Enrique | article | openAccess |
| 47 | 2005 | Redox interactions of nitric oxide with dopamine and its derivatives | Antunes, Fernando ; Nunes, Carla ; Laranjinha, João ; Cadenas, Enrique | article | openAccess |
| 48 | 3-Oct-2017 | Relatório de estágio e monografia intitulada :"mecanismos epigenéticos na formação de memória e capacidades cognitivas" | Brazão, João António Lima de Andrade Conde | masterThesis | openAccess |
| 49 | 14-Sep-2018 | Relatórios de Estágio e Monografia intitulada “Novas Estratégias Biomédicas: Modulação do Epigenoma e Terapia do Cancro" | Arrais, Débora Gomes | masterThesis | openAccess |
| 50 | 3-Oct-2017 | Relatórios de Estágio e Monografia intitulada “O Parkinson, a Microbiota Intestinal e a Epigenética” | Silva, Miguel Pereira da | masterThesis | openAccess |
| 51 | Aug-2016 | Role of nitrite, urate and pepsin in the gastroprotective effects of saliva | Rocha, Bárbara S. ; Lundberg, Jon O. ; Radi, Rafael; Laranjinha, João | article | openAccess |
| 52 | Feb-2013 | Self-mixing microprobe for monitoring microvascular perfusion in rat brain | Figueiras, Edite ; Oliveira, Ricardo ; Lourenço, Cátia F. ; Campos, Rita ; Humeau-Heurtier, Anne ; Barbosa, Rui M. ; Laranjinha, João ; Requicha Ferreira, Luís F. ; de Mul, Frits F M | article | openAccess |
| 53 | Jul-2016 | Síndrome metabólico e dieta vegetariana: relação benéfica, deletéria ou irrelevante? | Lijnzaat, Pedro de Azevedo | other | openAccess |
| 54 | Jul-2016 | The human microbiome: a fine line between symbiosis and pathogenesis | Gonçalves, João Miguel da Silva | other | openAccess |
| 55 | 1-Apr-2016 | The interplay of ascorbic acid, nitric oxide and nitrite in the brain and its role on the regulation of cerebral blood flow: an in vivo electrochemical study | Ferreira, Nuno Ricardo Esteves | doctoralThesis | openAccess |
| 56 | Sep-2016 | The long and winding road of STAT3 in the mitochondria | Ramos, Carlos Eduardo Cardanho dos | other | openAccess |
| 57 | Jul-2016 | The pathogenesis of Parkinson Disease : the microbiota-gut-brain axis | Fernandes, Ana Rita Cardoso | other | openAccess |
| 58 | 9-May-2013 | The redox interplay between nitrite and nitric oxide: From the gut to the brain | Pereira, Cassilda ; Ferreira, Nuno R. ; Rocha, Bárbara S. ; Barbosa, Rui M. ; Laranjinha, João | article | openAccess |
| 59 | 18-May-2016 | The role of nitrite-derived nitric oxide in gastric physiology: biochemical mechanisms, molecular targets and the modulatory effect of red wine | Pereira, Cassilda Maria Lopes | doctoralThesis | openAccess |
| 60 | 2011 | The role of polyphenols and reactive nitrogen species in inflammatory conditions of the gastrointestinal tract| | Ferreira, Elisabete Priscila Pinto | masterThesis | openAccess |
| 61 | 18-Jan-2013 | Unravelling New Roles for SIRT1 in Mitochondrial Biollogy | Gomes, Ana Patrícia da Silva | doctoralThesis | openAccess |