Ferreiro, Elisabete
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Credit Name
Ferreiro, Elisabete
Name
Ferreiro, E.
Personal Site
http://www.cnbc.pt/research/department_group_show.asp?iddep=1138&idgrp=1141
Ciência ID
Status
UC Researcher
Biography
Elisabete Ferreiro is currently an assistant researcher at the Center for Neuroscience and Cell Biology, University of Coimbra, integrated in the group MitoXT - Mitochondrial Toxicology and Experimental Therapeutics, headed by Dr.Paulo Oliveira. She graduated in Biology from the University of Coimbra (UC), in 2002, and completed her PhD degree in Biology, also from UC, in 2008. Her main expertise area is in neuroscience and cell biology. Her research in the past years has been focused on identifying mechanisms involved in Alzheimer's disease (AD) and potential therapeutic targets for the treatment of this neurodegenerative disease. She was also interested in exploring hippocampal adult neurogenesis along with signalling pathways with potential to improve upon it. Her PhD works, supervised by Prof. Claudia Fragão Pereira (Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra) led to the thesis 'Cross-talk between endoplasmic reticulum and mitochondria in the neurotoxicity induced by amyloid-beta and prion peptides. Implications for the etiopathogenesis of Alzheimer’s disease and Prion disorders'. During her PhD works, E. Ferreiro demonstrated the existence of endoplasmic reticulum (ER) stress as a major contribution for cell death induced by the amyloid beta (Abeta) peptide and PrP106–126, in both Alzheimer’s disease and Prion disorders. Besides, she further showed the relevance of the communication between the ER and the mitochondria for apopotic pathway. In 2008, E. Ferreiro started her post-doc research program in order to characterize the stem and progenitor properties that contribute for decreased neurogenesis in the triple transgenic mouse model of AD. In 2013, initiated a second postdoctoral program in the group of Dr Ana Cristina Rego (Faculty of Medicine and Center for Neuroscience and Cell Biology, University of Coimbra). During this period Elisabete Ferreiro studied the mitochondrial control of NMDA receptor-dependent calcium rise evoked by amyloid-ß 1-42 oligomers in rat cortical neurons and also evaluated whether hyperglycemia enhances AD pathology by modifying NMDARs signaling and function, and consequently affecting neurogenesis. In 2015, E Ferreiro joined the COST action BM1402, and was an active member and establishing several collaborations and short-term exchanges. In 2017 she spent 6 months at the Achucarro Basque Center (Spain), where she extended her knowledge on hippocampal neurogenesis, and consolidate her ollaborations with experts in the field. Currently, she is currently interested in developing new therapeutic strategies, for other Neurodegenerative diseases, such as Amyotrophic lateral sclerosis. As a result of her research activity, she has published 32 scientific papers in international peer reviewed journals, with over 2122 citations and a h index of 21.
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Publications
(All)
Results 1-18 of 18 (Search time: 0.024 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | Dec-2013 | Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells | Fonseca, Ana Catarina R. G. ; Ferreiro, Elisabete ; Oliveira, Catarina R. ; Cardoso, Sandra M. ; Pereira, Cláudia F. | article | openAccess |
| 2 | Feb-2015 | Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release | Ferreira, Ildete Luísa ; Ferreiro, Elisabete ; Schmidt, Jeannette ; Cardoso, João M. ; Pereira, Cláudia M. F. ; Carvalho, Ana Luísa ; Oliveira, Catarina R. ; Rego, A. Cristina | article | openAccess |
| 3 | 2004 | Cell degeneration induced by amyloid-ß peptides | Pereira, Cláudia ; Ferreiro, Elisabete ; Cardoso, Sandra ; Oliveira, Catarina de | article | openAccess |
| 4 | Aug-2020 | Chronic hyperglycemia impairs hippocampal neurogenesis and memory in an Alzheimer's disease mouse model | Ferreiro, Elisabete | article | openAccess |
| 5 | 26-Apr-2019 | Chronic stress triggers divergent dendritic alterations in immature neurons of the adult hippocampus, depending on their ultimate terminal fields | Dioli, Chrysoula; Patrício, Patrícia; Sousa, Nuno; Kokras, Nikolaos; Dalla, Christina; Guerreiro, Sara ; Santos-Silva, Miguel A.; Rego, Ana Cristina ; Pinto, Luísa ; Ferreiro, Elisabete ; Sotiropoulos, Ioannis | article | openAccess |
| 6 | 31-Aug-2018 | Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus | Ferreiro, Elisabete ; Pita, Inês R. ; Mota, Sandra ; Valero, Jorge ; Ferreira, Nuno R. ; Fernandes, Tito; Calabrese, Vittorio; Fontes-Ribeiro, Carlos A. ; Pereira, Frederico C. ; Rego, Ana Cristina | article | openAccess |
| 7 | 2022 | Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice | Fernandes, Adelaide; Caldeira, Cláudia; Cunha, Carolina; Ferreiro, Elisabete ; Vaz, Ana Rita; Brites, Dora | article | openAccess |
| 8 | 2006 | An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity | Ferreiro, Elisabete ; Resende, Rosa ; Costa, Rui ; Oliveira, Catarina R. ; Pereira, Cláudia M. F. | article | openAccess |
| 9 | 2008 | ER stress is involved in Abeta-induced GSK-3beta activation and tau phosphorylation | Resende, Rosa ; Ferreiro, Elisabete ; Pereira, Cláudia ; Oliveira, Catarina Resende | article | openAccess |
| 10 | 2004 | Involvement of endoplasmic reticulum Ca2+ release through ryanodine and inositol 1,4,5-triphosphate receptors in the neurotoxic effects induced by the amyloid-beta peptide | Ferreiro, Elisabete ; Oliveira, Catarina R. ; Pereira, Cláudia | article | openAccess |
| 11 | 2014 | Involvement of vascular dysfunction in the neurogenesis impairment that occurs in Alzheimer’s disease | Fontes, Ana Raquel | masterThesis | openAccess |
| 12 | 6-Mar-2020 | miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease | Barros-Viegas, Ana Teresa ; Carmona, Vitor ; Ferreiro, Elisabete ; Guedes, Joana ; Cardoso, Ana Maria S. ; Cunha, Pedro ; Almeida, Luís Pereira de ; Oliveira, Catarina Resende de ; Magalhães, João Pedro de ; Peça, João ; Cardoso, Ana Luísa | article | openAccess |
| 13 | 2012 | Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers | Ferreiro, E. ; Baldeiras, I. ; Ferreira, I. L. ; Costa, R. O. ; Rego, A. C. ; Pereira, C. F. ; Oliveira, C. R. | article | openAccess |
| 14 | 1-Sep-2008 | Neurotoxic effect of oligomeric and fibrillar species of A<beta>1-42 peptide. Involvement of ER calcium release in oligomers-induced cell death. | Resende, Rosa ; Ferreiro, Elisabete ; Pereira, Cláudia ; Oliveira, Catarina Resende de | article | openAccess |
| 15 | 1-Jul-2023 | Recent Advances in Extracellular Vesicles in Amyotrophic Lateral Sclerosis and Emergent Perspectives | Afonso, Gonçalo; Cavaleiro, Carla ; Valero, Jorge ; Mota, Sandra ; Ferreiro, E. | article | openAccess |
| 16 | 2008 | The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway | Ferreiro, Elisabete ; Oliveira, Catarina R. ; Pereira, Cláudia M. F. | article | openAccess |
| 17 | Oct-2017 | Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus | Robledinos-Antón, Natalia; Rojo, Ana I; Ferreiro, Elisabete ; Núñez, Ángel; Krause, Karl-Heinz; Jaquet, Vincent; Cuadrado, Antonio | article | openAccess |
| 18 | 2020 | Unraveling the Nanoscopic Organization and Function of Central Mammalian Presynapses With Super-Resolution Microscopy | Carvalhais, Lia G. ; Martinho, Vera C. ; Ferreiro, Elisabete ; Pinheiro, Paulo S. | article | openAccess |