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This work was supported by Fundação para a Ciência e Tecnologia (FCT) grants (PTDC/SAUFCF/ 81436/2006; PTDC/SAU-MIC/115598/2009), by FEDER funds through the Operational Programme Competitiveness Factors - COMPETE and national funds by FCT -Foundation for Science and Technology under the strategic project UID / NEU / 04539 / 2013; and also by NARSAD. LR is a recipient of a PhD grant by FCT (SFRH/BD/74181/2010). IMM is supported by FCT (BPD/113285/2015), FEDER and COMPETE.