This research was supported by a grant from the Netherlands Organization for Scientific Research (NWO, No: 911-02-008, instrumentation) and a grant from the Institute for Genetic and Metabolic Disease (IGMD) of the Radboudumc (to WJHK). Grants to JT (PTDC/ DTP-FTO/2433/2014 and NORTE-01-0145-FEDER-000028) are supported by the European Regional Development Fund (ERDF) through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT–Fundação para a Ciência e a Tecnologia. Further support was provided by European Regional Development Fund (ERDF) through the COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT–Fundação para a Ciência e a Tecnologia (projects: POCI-01-0145-FEDER-007440, PTDC/DTP-FTO/2433/2014 and POCI-01-0145-FEDER-016659)