This work was supported by the Portuguese Foundation for Science and Technology (Fundação para a Ciência e a Tecnologia) — FCT — grant FCT-UID/NEU/04539/2019 and by the European Regional Development Fund (ERDF/FEDER) through the Operational Program Competitiveness Factors (Programa Operacional Factores de Competitividade) — COMPETE — funding through Project ‘Stem cell based platforms for Regenerative and Therapeutic Medicine’, Centro-07-ST24-FEDER-002008. M.G. acknowledges funding by the ERDF/FEDER through COMPETE and by national funds by FCT through grant FCOMP-01–0124-FEDER-021150 - PTDC/ SAU-889 ENB/119292/2010 and grant POCI-01–0145-FEDER-029516, co-financed by the ERDF/FEDER under the framework Competitiveness and Internationalization Operational Program (Programa Operacional Competitividade e Internacionalização — POCI) and by national funds through FCT/‘Ministério da Ciência, Tecnologia e Ensino Superior’ (FCT/MCTES) through the Portuguese State Budget. Grant PTDC/SAUENB/ 113696/2009 was attributed to R.P.N., and A.L. was recipient of the fellowship FCT - SFRH/BD/51942/2012 (all from FCT and co-financed by FEDER). R.D.M.T. and J.C. thank the support of FEDER funds through COMPETE and by national funds by FCT under the strategic project UID/FIS/04564/2016 and under POCI-01- 0145-FEDER-031743 - PTDC/BIA-CEL/31743/2017. R.D.M.T. acknowledges FCT’s support through the FCT Researcher Program.