This work was supported by Fundaç~ao para a Ci^encia e a Tecnologia (FCT) (projects UID/QUI/00100/ 2013, UID/MULTI/04349/2013, UID/BIO/04565/2013, RECI/QEQ-QIN/0189/2012, RECI/QEQ-MED/0330/ 2012, IF/01179/2013), Programa Operacional Regional de Lisboa (LISBOA-01-0145-FEDER-007317) and programme Investigador FCT (FSE, POPH). The Portuguese NMR and Mass Spectrometry ISTeUL Centers are acknowledged for the access to the equipment. The authors thank Fernanda Marques for a preliminary cytotoxicity assessment of the compounds and also Ali Cenk Aksu for calculating the IC50 values. This work was supported by Koç University School of Medicine (KUSOM) and the authors gratefully acknowledge use of the services and facilities of the Koç University Research Center for Translational Medicine (KUTTAM), funded by the Republic of Turkey Ministry of Development. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Ministry of Development.