The work was supported by Portuguese Fundação para a Ciência e Tecnologia (FCT) through funding to BioISI (Ref: UID/MULTI/04046/2013), LASIGE Research Unit (Ref: UID/CEC/00408/2019), and to DeST: Deep Semantic Tagger project (Ref: PTDC/CCI-BIO/28685/2017). M.A., A.R.M., J.X.S., and J.V. were the recipients of BioSys PhD programme fellowship from FCT (Portugal) with references PD/ BD/52485/2014, PD/BD/113773/2015, PD/BD/114386/2016, and PD/BD/ 131390/2017, respectively. C.R. is the recipient of a grant from FCT (Ref: POCI- 01-0145-FEDER-016428). Patients and parents were genotyped in the context of the Autism Genome Project (AGP), funded by NIMH, HRB, MRC, Autism Speaks, Hilibrand Foundation, Genome Canada, OGI, and CIHR.