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This work resulted from a collaboration initiated by the COST Action CA15214 (EuroCellNet). MG and RDMT thank the support of FEDER funds through the Operational Program Competitiveness Factors - COMPETE and by national funds by FCT - Foundation for Science and Technology under the strategic project UID/FIS/ 04564/2016 and under PTDC/BIA-CEL/31743/ 2017. MG thanks support by UE/FEDER funds through the program COMPETE 2020, under the project CENTRO-01-0145-FEDER-000014 (MATIS). RDMT acknowledges FCT’s support through the FCT Researcher Program. The work was also supported by Slovenian Research Agency Program Grants P1-0055 (JD, BS and SZJ)and P1- 0390 (ML). This work was supported by the Republic of Slovenia Ministry of Education, Science and Sport and the EraCoSysMed (JTC-2 2017) "4D-HEALING" grant, and the Celsa Alliance grant to ML (prof Radovan Komel).