This work has been conducted during the Fulbright visiting scholarship awarded to Prof. Dr. Mohammad Sanad Abu-Darwish during his Sabbatical leave from Al-Balqa’ Applied University, Al-Salt, Jordan, at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, USA. The authors thank the Dean of Scientific Research, Al-Balqa Applied University, Jordan, the Binational Fulbright Commission in Jordan, Council for International Exchange of Scholars (CIES), and Institute of International Education (IIE), USA. This work was also supported by Foundation for Science and Technology (FCT), Portugal (Strategic Projects UID/NEU/04539/2013 ,and UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/04539/2020 (CIBB)).

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This work has been conducted during the Fulbright visiting scholarship awarded to Prof. Dr. Mohammad Sanad Abu-Darwish during his Sabbatical leave from Al-Balqa’ Applied University, Al-Salt, Jordan, at the National Center for Natural Products Research, School of Pharmacy, University of Mississippi, USA. The authors thank the Dean of Scientific Research, Al-Balqa Applied University, Jordan, the Binational Fulbright Commission in Jordan, Council for International Exchange of Scholars (CIES), and Institute of International Education (IIE), USA. This work was also supported by Foundation for Science and Technology (FCT), Portugal (Strategic Projects UID/NEU/04539/2013 ,and UID/NEU/04539/2019, UIDB/04539/2020 and UIDP/04539/2020 (CIBB)).