This work was supported in part by a grant fromthe National Institutes of Health (R01 AG032643), a grant from the American Heart Association (14GRNT18890084), and through an Institutional DevelopmentAward (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (www.nigms.nih.gov) under grant number P20 GM109005. Part of this research was supported by the Arkansas High Performance Computing Center which is funded through multiple National Science Foundation grants and the Arkansas Economic Development Commission. Part of this research was supported by UIDB/04539/2020 and P20GM109096. The authors would like to acknowledge the Metabolomics Shared Resource at Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008. Part of this research was-based upon work supported by the National Science Foundation under Award No. OIA-1946391. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.

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This work was supported in part by a grant fromthe National Institutes of Health (R01 AG032643), a grant from the American Heart Association (14GRNT18890084), and through an Institutional DevelopmentAward (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (www.nigms.nih.gov) under grant number P20 GM109005. Part of this research was supported by the Arkansas High Performance Computing Center which is funded through multiple National Science Foundation grants and the Arkansas Economic Development Commission. Part of this research was supported by UIDB/04539/2020 and P20GM109096. The authors would like to acknowledge the Metabolomics Shared Resource at Georgetown University (Washington, DC, USA) which is partially supported by NIH/NCI/CCSG grant P30-CA051008. Part of this research was-based upon work supported by the National Science Foundation under Award No. OIA-1946391. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.