This work was supported by grants funded by Fundação para a Ciência e Tecnologia, PAC –286 MEDPERSYST, POCI-01-0145- FEDER-016428, BIGDATIMAGE, CENTRO-01-0145-FEDER- 000016 financed by Centro 2020 FEDER, COMPETE, FCT UID/4950/2020, CONECT-BCI (POCI-01-0145-FEDER-030852, PCIF/SSO/0082/2018) and Bial Foundation 252/18

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This work was supported by grants funded by Fundação para a Ciência e Tecnologia, PAC –286 MEDPERSYST, POCI-01-0145- FEDER-016428, BIGDATIMAGE, CENTRO-01-0145-FEDER- 000016 financed by Centro 2020 FEDER, COMPETE, FCT UID/4950/2020, CONECT-BCI (POCI-01-0145-FEDER-030852, PCIF/SSO/0082/2018) and Bial Foundation 252/18