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This research was funded by research grants from the Excellence of Diabetes Research in Sweden (EXODIAB), European Commision via the Marie Sklodowska Curie Innovative Training Network TREATMENT (H2020-MSCA-ITN-721236), the Uppsala University Hospital ALF grants, Svenska Sällskapet för Medicinsk Forskning (Swedish Society for Medical Research), the Diabetes Foundation (Swedish Diabetes Association), the Ernfors Foundation, and the P.O Zetterling Foundation.