This work was developed within the scope of iBiMED (UIDB/ 04501/2020) and CICECO-Aveiro Institute of Materials (UIDB/ 50011/2020 & UIDP/50011/2020), financed by national funds through the Foundation for Science and Technology (FCT). Funding was received from the project ImmunoDCs@ CancerStemCells: Cellular Immunotherapy toward the elimination of cancer stem cells (Ref.: POCI-01-0247-FEDER- 033532), co-funded by the European Regional Development Fund (FEDER), Competitiveness and Internationalization Operational Program (COMPETE2020) and Own Revenues of the University of Coimbra. João Calmeiro and Luı́s Mendes are supported by the FCT through individual PhD fellowships (PD/BDE/135076/2017; PD/BD/147220/2019). The NMR spectrometer is part of the National NMR Network (PTNMR), partially supported by Infrastructure Project N° 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).