This work was partially supported by the Portuguese ‘Fundação para a Ciência e a Tecnologia’ (FCT) through the project exo-Heart POCI-01-0145-FEDER-029919, co-funded by COMPETE2020- UE and CENTRO-01-0145-FEDER-000014 through ‘Programa Operacional Regional do Centro’ CENTRO2020; Project “NeuroAtlantic”, Ref: EAPA_791/2018, which is co-funded by Program Interreg Atlantic Space through European fund for Regional Development. Project 0624_2IQBIONEURO_6_E, funded by the European Regional Development Fund (ERDF) through an INTERREG V A España Portugal (POCTEP) 2014-2020. Project LABEL- Radio-labeling of extracellular vesicles for applications in diagnostic and therapeutics” funded by FEDER through Portugal2020 program. European Union’s Horizon 2020 research and innovation program under grant agreement number 764958 (project NANOSTEM) and grant agreement number 669088 (project ERAatUC). Furthermore, this study was also supported by grants from the Xunta de Galicia (Consellería de Economía e Industria: IN607D2020/09), Science Ministry of Spain (RTI2018-102165-B-I00), and Dr. Sobrino (CPII17/00027), is recipient of a research contract from the Miguel Servet Program (Instituto de Salud Carlos III).

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This work was partially supported by the Portuguese ‘Fundação para a Ciência e a Tecnologia’ (FCT) through the project exo-Heart POCI-01-0145-FEDER-029919, co-funded by COMPETE2020- UE and CENTRO-01-0145-FEDER-000014 through ‘Programa Operacional Regional do Centro’ CENTRO2020; Project “NeuroAtlantic”, Ref: EAPA_791/2018, which is co-funded by Program Interreg Atlantic Space through European fund for Regional Development. Project 0624_2IQBIONEURO_6_E, funded by the European Regional Development Fund (ERDF) through an INTERREG V A España Portugal (POCTEP) 2014-2020. Project LABEL- Radio-labeling of extracellular vesicles for applications in diagnostic and therapeutics” funded by FEDER through Portugal2020 program. European Union’s Horizon 2020 research and innovation program under grant agreement number 764958 (project NANOSTEM) and grant agreement number 669088 (project ERAatUC). Furthermore, this study was also supported by grants from the Xunta de Galicia (Consellería de Economía e Industria: IN607D2020/09), Science Ministry of Spain (RTI2018-102165-B-I00), and Dr. Sobrino (CPII17/00027), is recipient of a research contract from the Miguel Servet Program (Instituto de Salud Carlos III).