%PDF-1.3
%
307 0 obj
<<
/Linearized 1
/O 310
/H [ 1864 875 ]
/L 332178
/E 52032
/N 12
/T 325919
>>
endobj
xref
307 65
0000000016 00000 n
0000001651 00000 n
0000001823 00000 n
0000002739 00000 n
0000003002 00000 n
0000003068 00000 n
0000003305 00000 n
0000003403 00000 n
0000003496 00000 n
0000003612 00000 n
0000003760 00000 n
0000004033 00000 n
0000004704 00000 n
0000005149 00000 n
0000005384 00000 n
0000006091 00000 n
0000006132 00000 n
0000006332 00000 n
0000007020 00000 n
0000007555 00000 n
0000007577 00000 n
0000007766 00000 n
0000008054 00000 n
0000008729 00000 n
0000009030 00000 n
0000009095 00000 n
0000009331 00000 n
0000009645 00000 n
0000010417 00000 n
0000010439 00000 n
0000011162 00000 n
0000011184 00000 n
0000011497 00000 n
0000011737 00000 n
0000011939 00000 n
0000012013 00000 n
0000012837 00000 n
0000013591 00000 n
0000013613 00000 n
0000014206 00000 n
0000014450 00000 n
0000015185 00000 n
0000015207 00000 n
0000015783 00000 n
0000016055 00000 n
0000016355 00000 n
0000016574 00000 n
0000016680 00000 n
0000017485 00000 n
0000017507 00000 n
0000018336 00000 n
0000018358 00000 n
0000019121 00000 n
0000019143 00000 n
0000021818 00000 n
0000027785 00000 n
0000027864 00000 n
0000030237 00000 n
0000035252 00000 n
0000036169 00000 n
0000036399 00000 n
0000037146 00000 n
0000049971 00000 n
0000001864 00000 n
0000002717 00000 n
trailer
<<
/Size 372
/Info 303 0 R
/Root 308 0 R
/Prev 325908
/ID[<86c0d4e4e8311058e50edb231d91bf39><86c0d4e4e8311058e50edb231d91bf39>]
>>
startxref
0
%%EOF
308 0 obj
<<
/Type /Catalog
/Pages 305 0 R
/Outlines 311 0 R
/Names 309 0 R
/OpenAction [ 310 0 R /FitH 804 ]
/PageMode /UseOutlines
/PageLabels 302 0 R
>>
endobj
309 0 obj
<<
/Dests 299 0 R
>>
endobj
370 0 obj
<< /S 624 /T 808 /O 864 /E 880 /L 896 /Filter /FlateDecode /Length 371 0 R >>
stream
Hb```f````c`y @1vgBmqH1t0iߓ)>=$<CE+V\6/p,tvS3t*պ)VM㬋[^VX+b2O7K{3y^XIsGvShM#$=QWI桖WWN0щuU-a%OhKL=Pp~˖ χsrnOiyJF.Y!:Ϣ!V àR{b']P(XoЊO&x1Zki
B2n KhhDGGD@444a*@TRRR@V7@iiHF1 ?! iEApőRs\Iv3j6@
cc>t\*RNk|5120p850m0mTށw. O&k
LZ/BxF<=iz%ÓI_83;4tiᚰ Aslxn1=UbxAE5^a`9H8LG8AX
˃pNbghNҰz?;' c"(
@=ˣ@d:,!* Y
endstream
endobj
371 0 obj
738
endobj
310 0 obj
<<
/Type /Page
/Parent 304 0 R
/Resources 317 0 R
/Contents [ 334 0 R 336 0 R 343 0 R 347 0 R 354 0 R 356 0 R 358 0 R 367 0 R ]
/Annots [ 315 0 R 316 0 R ]
/Thumb 212 0 R
/MediaBox [ 0 0 544 743 ]
/CropBox [ 0 0 544 743 ]
/Rotate 0
>>
endobj
311 0 obj
<<
/Count 3
/First 312 0 R
/Last 312 0 R
>>
endobj
312 0 obj
<<
/Title (4-Hydroxytamoxifen induces slight uncoupling of mitochondrial oxidative \
phosphorylation system in relation to the deleterious e)
/Dest (bkmatl)
/Parent 311 0 R
/First 313 0 R
/Last 314 0 R
/Count 2
>>
endobj
313 0 obj
<<
/Title (Acknowledgements)
/Dest (bkmack)
/Parent 312 0 R
/Next 314 0 R
>>
endobj
314 0 obj
<<
/Title (References)
/Dest (bkmbibl)
/Parent 312 0 R
/Prev 313 0 R
>>
endobj
315 0 obj
<<
/Dest (bkcor1)
/Type /Annot
/Subtype /Link
/Rect [ 330 465 336 478 ]
/Border [ 0 0 0 ]
>>
endobj
316 0 obj
<<
/A << /URI (mailto:custodio@ci.uc.pt)/S /URI >>
/Type /Annot
/Subtype /Link
/Rect [ 107 72 168 80 ]
/Border [ 0 0 0 ]
>>
endobj
317 0 obj
<<
/ProcSet [ /PDF /Text /ImageB ]
/Font << /F1 324 0 R /F2 318 0 R /F3 321 0 R /F4 327 0 R /F5 329 0 R /F6 340 0 R
/F7 345 0 R /F8 352 0 R >>
/XObject << /Im1 368 0 R /Im2 369 0 R >>
/ExtGState << /GS1 362 0 R >>
/ColorSpace << /Cs6 322 0 R >>
>>
endobj
318 0 obj
<<
/Type /Font
/Subtype /Type1
/FirstChar 32
/LastChar 177
/Widths [ 250 270 406 666 500 822 770 177 333 333 500 666 270 333 270 281 500
500 500 500 500 500 500 500 500 500 270 270 666 666 666 385 916
770 666 718 822 666 666 822 822 385 437 822 666 989 822 770 604
770 770 552 666 822 718 989 770 770 666 270 281 270 468 500 333
500 552 437 552 437 333 500 552 270 270 552 270 822 552 552 552
552 385 385 333 552 500 718 500 500 437 479 197 479 541 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 437
500 0 0 0 0 0 0 0 0 0 0 0 0 0 666 ]
/Encoding /WinAnsiEncoding
/BaseFont /MBNKEI+AdvTR
/FontDescriptor 320 0 R
>>
endobj
319 0 obj
<<
/Type /FontDescriptor
/Ascent 717
/CapHeight 675
/Descent -204
/Flags 34
/FontBBox [ -260 -239 1093 708 ]
/FontName /MBNKEK+AdvP497E3
/ItalicAngle 0
/StemV 0
/XHeight 457
/CharSet (/f/period/colon/h/P/F/w/slash/d/i/L/N/y/zero/M/z/n/cedilla/one/A/dotless\
i/two/m/x/three/o/K/parenleft/p/acute/E/parenright/four/S/T/q/five/U/cir\
cumflex/g/B/r/six/b/C/s/a/seven/c/l/comma/t/e/hyphen/u/nine)
/FontFile3 364 0 R
>>
endobj
320 0 obj
<<
/Type /FontDescriptor
/Ascent 717
/CapHeight 687
/Descent -211
/Flags 34
/FontBBox [ -83 -239 1000 718 ]
/FontName /MBNKEI+AdvTR
/ItalicAngle 0
/StemV 0
/XHeight 464
/CharSet (/v)
/FontFile3 366 0 R
>>
endobj
321 0 obj
<<
/Type /Font
/Subtype /Type1
/FirstChar 25
/LastChar 184
/Widths [ 270 0 0 0 0 0 0 250 270 406 666 500 822 718 177 500 500 500 666 270
333 270 281 500 500 500 500 500 500 500 500 500 500 333 333 666
666 666 385 916 718 666 718 770 666 604 718 822 385 500 718 666
989 770 770 666 770 718 604 666 770 718 989 718 718 718 500 281
500 427 500 333 500 500 437 500 437 333 500 500 270 270 531 270
770 500 500 500 500 385 385 333 500 437 666 552 500 437 479 270
479 541 0 0 0 0 0 0 0 0 0 333 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0 0 0 0 0 0 250 0 500 500 0 0 0 0 0 0 0 0 0 333 0 0 0 666 0 0 333
0 0 0 333 ]
/Encoding 323 0 R
/BaseFont /MBNKEK+AdvP497E3
/FontDescriptor 319 0 R
>>
endobj
322 0 obj
[
/ICCBased 360 0 R
]
endobj
323 0 obj
<<
/Type /Encoding
/BaseEncoding /WinAnsiEncoding
/Differences [ 19 /Lslash /lslash /minus /fraction /breve /caron /dotlessi /dotaccent
/hungarumlaut /ogonek /ring /fi /fl ]
>>
endobj
324 0 obj
<<
/Type /Font
/Subtype /Type1
/FirstChar 30
/LastChar 180
/Widths [ 552 552 250 270 406 666 500 822 770 177 333 333 500 666 270 333 270
281 500 500 500 500 500 500 500 500 500 500 270 270 666 666 666
385 916 770 666 718 822 666 666 822 822 385 437 822 666 989 822
770 604 770 770 552 666 822 718 989 770 770 666 270 281 270 468
500 333 500 552 437 552 437 333 500 552 270 270 552 270 822 552
552 552 552 385 385 333 552 500 718 500 500 437 479 197 479 541
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 270 0 0 0 0 0 0 0 0 0 0 0
0 0 250 0 437 500 0 0 0 0 0 0 0 0 0 333 0 0 0 666 0 0 333 ]
/Encoding 323 0 R
/BaseFont /MBNKEG+AdvP497E2
/FontDescriptor 325 0 R
>>
endobj
325 0 obj
<<
/Type /FontDescriptor
/Ascent 717
/CapHeight 687
/Descent -211
/Flags 34
/FontBBox [ -83 -239 1000 718 ]
/FontName /MBNKEG+AdvP497E2
/ItalicAngle 0
/StemV 0
/XHeight 464
/CharSet (/six/M/b/z/seven/O/c/quoteright/eight/e/nine/parenleft/f/R/fi/colon/h/ac\
ute/parenright/S/fl/semicolon/i/U/asterisk/g/j/V/k/K/W/comma/m/l/X/hyphe\
n/Y/o/period/Z/n/p/P/at/slash/bracketleft/T/q/B/zero/r/A/C/one/s/bracket\
right/a/D/two/t/G/three/x/u/N/H/I/E/v/four/J/dollar/F/w/five/L/percent/d\
/y)
/FontFile3 361 0 R
>>
endobj
326 0 obj
692
endobj
327 0 obj
<<
/Type /Font
/Subtype /Type1
/FirstChar 1
/LastChar 1
/Widths [ 437 ]
/Encoding 331 0 R
/BaseFont /MBNKEM+AdvBM2
/FontDescriptor 332 0 R
/ToUnicode 328 0 R
>>
endobj
328 0 obj
<< /Filter /FlateDecode /Length 213 >>
stream
HT0>GCRXJҁQ.{H*u"7EI
!ObSm+đ1@c0n`pK0Vw7V)"U8(L~w˅8A]a@BY&{! ȊZB om"ͫZH^Y$&-icq1Q` ?' \Hh
endstream
endobj
329 0 obj
<<
/Type /Font
/Subtype /Type1
/FirstChar 32
/LastChar 177
/Widths [ 250 270 552 666 500 875 770 281 333 333 500 666 270 333 270 281 500
500 500 500 500 500 500 500 500 500 270 270 666 666 666 385 927
718 666 718 770 666 604 770 822 385 552 718 666 989 770 822 666
822 718 604 666 770 718 989 718 718 718 270 281 270 583 500 333
500 500 437 500 437 333 500 500 270 270 552 270 770 500 500 500
500 385 385 333 500 437 666 552 500 437 395 218 395 520 0 0 0 0
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 437
500 0 0 0 0 0 0 0 0 0 0 0 0 0 666 ]
/Encoding /WinAnsiEncoding
/BaseFont /MBNKFO+AdvP497E4
/FontDescriptor 333 0 R
>>
endobj
330 0 obj
<< /Length 230 /Subtype /Type1C >>
stream
MBNKEM+AdvBM2 )nmy AdvBM2 v W I}~SU~_yX`m~Ùpzwzx}zzvz\]zbnAT89tvx|pmyyS`Ul]
endstream
endobj
331 0 obj
<<
/Type /Encoding
/Differences [ 1 /v ]
>>
endobj
332 0 obj
<<
/Type /FontDescriptor
/Ascent 710
/CapHeight 670
/Descent -208
/Flags 6
/FontBBox [ -250 -218 1072 729 ]
/FontName /MBNKEM+AdvBM2
/ItalicAngle 0
/StemV 0
/XHeight 458
/CharSet (/v)
/FontFile3 330 0 R
>>
endobj
333 0 obj
<<
/Type /FontDescriptor
/Ascent 687
/CapHeight 687
/Descent -211
/Flags 34
/FontBBox [ -187 -239 1062 718 ]
/FontName /MBNKFO+AdvP497E4
/ItalicAngle 0
/StemV 0
/XHeight 464
/CharSet (/k/g/two/m/b/w/three/o/d/c/R/l/D/four/e/n/f/I/period/r/h/s/a/i/t/M/u/one\
/A)
/FontFile3 363 0 R
>>
endobj
334 0 obj
<< /Filter /FlateDecode /Length 326 0 R >>
stream
HTn0z.5oi4@tSInv):M@!آH.wfvˮn^